In vivo protective effects of upper zone of growth plate and cartilage matrix associated protein against cartilage degeneration in a monosodium iodoacetate induced osteoarthritis model
Yükleniyor...
Dosyalar
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Canadian Science Publishing
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Osteoarthritis (OA) is a degenerative disease affecting the majority of over 65 year old people and characterized by cartilage degeneration, subchondral abnormal changes, and inflammation. Despite the enormous socioeconomic burden caused by OA, currently, there is no effective therapy against it. Upper zone of growth plate and cartilage matrix associated protein (UCMA) is a vitamin K dependent protein and has a critical role in pathophysiological conditions associated with bone and cartilage. However, there is no research on the protective role of intra-articular UCMA treatment in OA pathogenesis. Therefore, we aimed to investigate the potential therapeutic role of UCMA in an in vivo model of OA. We report for the first time that intra-articular UCMA injection ameliorated cartilage degeneration in a monosodium iodoacetate induced OA rat model. Furthermore, the OA-induced activation of nuclear factor kappa B and bone morphogenetic protein 2 signals was attenuated by UCMA. Our results indicated that UCMA decreased cartilage oligomeric matrix protein levels but did not affect interleukin 6, total antioxidant status, and total oxidant status levels in the serum. In conclusion, UCMA exhibited a therapeutic potential in the treatment of OA. This protective effect of UCMA is possibly achieved by reducing the aggrecanase activity and the production of inflammatory cytokines. © 2020, Canadian Science Publishing. All rights reserved.
Açıklama
Anahtar Kelimeler
Cartilage degeneration, Monosodium iodoacetate, Osteoarthritis, Oxidative stress, Rat osteoarthritis model, Total antioxidant status, Total oxidant status, UCMA, antirheumatic agent, bone morphogenetic protein 2, cartilage oligomeric matrix protein, diclofenac, glycosaminoglycan, immunoglobulin enhancer binding protein, interleukin 6, iodoacetic acid, isoflurane, monosodium iodoacetate, proteoglycan, sodium chloride, unclassified drug, upper zone of growth plate and cartilage matrix associated protein, vitamin K group, aggrecanase, cytokine, iodoacetic acid, proteinase, recombinant protein, signal peptide, Ucma protein, human, adult, animal experiment, animal model, animal tissue, Article, cartilage degeneration, cartilage matrix, chondroprotection, controlled study, disease association, drug mechanism, epiphysis plate, histopathology, in vivo study, male, medial tibial plateau, microscopy, molecular biology, nonhuman, osteoarthritis, oxidative stress, pathophysiology, priority journal, protein function, rat, therapy effect, animal, articular cartilage, drug effect, epiphysis plate, experimental arthritis, growth, development and aging, human, immunology, intraarticular drug administration, metabolism, osteoarthritis, pathology, signal transduction, Animals, Arthritis, Experimental, Cartilage, Articular, Cytokines, Endopeptidases, Growth Plate, Humans, Injections, Intra-Articular, Intercellular Signaling Peptides and Proteins, Iodoacetates, Male, Osteoarthritis, Rats, Recombinant Proteins, Signal Transduction
Kaynak
Canadian Journal of Physiology and Pharmacology
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
98
Sayı
11
