Investigation of serum macrophage migration inhibitor factor and monocyte chemotactic protein-1 levels in irritable bowel syndrome

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dc.authorid0000-0002-2270-2965
dc.authorscopusid8514414100
dc.authorscopusid55881189500
dc.authorscopusid36608599700
dc.authorscopusid56388498400
dc.authorscopusid55858591400
dc.authorscopusid25625782200
dc.authorscopusid36866111300
dc.authorwosidYilmaz, Ahsen/ABB-1083-2021
dc.contributor.authorTülübaş, Feti
dc.contributor.authorOran, Mustafa
dc.contributor.authorMete, Rafet
dc.contributor.authorTuran, Filiz
dc.contributor.authorYılmaz, Ahsen
dc.contributor.authorYıldız, Zeynep Deniz
dc.contributor.authorGürel, Ahmet
dc.date.accessioned2022-05-11T14:09:59Z
dc.date.available2022-05-11T14:09:59Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Anesteziyoloji ve Reanimasyon Ana Bilim Dalı
dc.description.abstractAim: Irritable bowel syndrome (IBS), a functional disorder of the bowel, has been thought to result from immune activation. The aim of this study was to evaluate macrophage migration inhibitory factor (MMIF) and monocyte chemotactic protein-1 (MCP-1) levels in IBS patients. Materials and methods: We enrolled 30 IBS patients and 30 healthy controls. The MMIF and MCP-1 levels of all patients and controls were detected using commercial enzyme-linked immunosorbent assay kits. Results: Serum MMIF and MCP-1 levels were markedly higher in IBS patients than in controls. White blood cell, neutrophil, lymphocyte, monocyte, eosinophil, and basophil counts did not differ significantly between groups. Conclusion: These results show that alterations in MMIF and MCP-1 affect the proinflammatory process. They also suggest that MMIF and MCP-1 may play a substantial role in IBS.
dc.identifier.doi10.3906/sag-1302-90
dc.identifier.endpage971
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue6en_US
dc.identifier.pmid25552148
dc.identifier.scopus2-s2.0-84908066326
dc.identifier.scopusqualityQ3
dc.identifier.startpage967
dc.identifier.urihttps://doi.org/10.3906/sag-1302-90
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5236
dc.identifier.volume44
dc.identifier.wosWOS:000344155900009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTülübaş, Feti
dc.institutionauthorOran, Mustafa
dc.institutionauthorMete, Rafet
dc.institutionauthorTuran, Filiz
dc.institutionauthorYılmaz, Ahsen
dc.institutionauthorYıldız, Zeynep Deniz
dc.institutionauthorGürel, Ahmet
dc.language.isoen
dc.publisherTubitak Scientific & Technical Research Council Turkey
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectIrritable bowel syndrome
dc.subjectmacrophage migration inhibitory factor
dc.subjectmonocyte chemotactic protein
dc.subjectinflammation
dc.subjectDendritic Cells
dc.subjectUlcerative-Colitis
dc.subjectCytokine
dc.subjectExpression
dc.subjectResponses
dc.subjectMif
dc.subjectAngiogenesis
dc.subjectGrowth
dc.titleInvestigation of serum macrophage migration inhibitor factor and monocyte chemotactic protein-1 levels in irritable bowel syndrome
dc.typeArticle

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