The effects of rivaroxaban, an oral anticoagulant, on human IVD primary cultures

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dc.authoridYILMAZ, Ibrahim/0000-0003-2003-6337
dc.authoridÖzbek, Hanefi/0000-0002-8084-7855
dc.authoridKaraarslan, Numan/0000-0001-5590-0637
dc.authorscopusid56674439000
dc.authorscopusid57216912962
dc.authorscopusid35197435300
dc.authorscopusid56674583800
dc.authorscopusid56769801000
dc.authorscopusid7005912992
dc.authorwosidYILMAZ, Ibrahim/H-6199-2019
dc.authorwosidÖzbek, Hanefi/O-3472-2019
dc.contributor.authorÇalışkan, Tezcan
dc.contributor.authorAkalan, Hande
dc.contributor.authorYılmaz, İbrahim
dc.contributor.authorKaraarslan, Numan
dc.contributor.authorŞirin, Duygu Yaşar
dc.contributor.authorÖzbek, Hanefi
dc.date.accessioned2023-04-20T08:01:13Z
dc.date.available2023-04-20T08:01:13Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Biyoloji Bölümü
dc.departmentYüksekokullar, Sağlık Yüksekokulu, Beslenme ve Diyetetik Bölümü
dc.description.abstractIntroduction: The present study aimed to investigate the potential effects of rivaroxaban, an oral anticoagulant that inhibits the effects of factor Xa, on intact intervertebral disc tissue cells and the extracellular matrix (ECM). Material and methods: Rivaroxaban was applied to primary human cell cultures prepared from tissues of the intervertebral disc. Comparative molecular analyses were performed on non-drug-treated control group samples. Descriptive statistics were presented as the mean +/- standard deviation. An analysis of variance test was performed to determine whether there were significant differences in the mean across the groups. When differences across groups were observed, Tukey's honestly significant difference post-hoc test was used for multiple pairwise comparisons. The significance of the obtained data was determined statistically. The alpha significance value was < 0.05. Results: The cells in the control group and in the rivaroxaban-treated group were viable, healthy, and proliferated (p < 0.05). However, the expression levels of the chondroadherin gene (CHAD), cartilage oligo matrix protein (COMP), matrix metalloproteinase (MMP)-13, and MMP-19 genes were changed (p < 0.05). Conclusions: Although rivaroxaban does not suppress cell proliferation due to morphological, biological, and biochemical changes in the intervertebral disc tissue, it may change the expression of genes that are related to ECM maintenance.
dc.identifier.doi10.5114/aoms/136323
dc.identifier.endpage1070
dc.identifier.issn1734-1922
dc.identifier.issn1896-9151
dc.identifier.issue4en_US
dc.identifier.pmid35832710
dc.identifier.scopus2-s2.0-85134502556
dc.identifier.scopusqualityQ2
dc.identifier.startpage1062
dc.identifier.urihttps://doi.org/10.5114/aoms/136323
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10800
dc.identifier.volume18
dc.identifier.wosWOS:000821077400017
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÇalışkan, Tezcan
dc.institutionauthorAkalan, Hande
dc.institutionauthorŞirin, Duygu Yaşar
dc.language.isoen
dc.publisherTermedia Publishing House Ltd
dc.relation.ispartofArchives of Medical Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCartilage Oligo Matrix Protein
dc.subjectChondroadherin Gene
dc.subjectCytotoxicity
dc.subjectIntervertebral Disc Cells
dc.subjectMatrix Metalloproteinases
dc.subjectNucleus Pulposus
dc.subjectRivaroxaban
dc.subjectOligomeric Matrix Protein
dc.subjectHippocampal Tissue
dc.subjectMetalloproteinases
dc.subjectInhibitor
dc.titleThe effects of rivaroxaban, an oral anticoagulant, on human IVD primary cultures
dc.typeArticle

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