Relationship between pruritus and autotaxin in intrahepatic cholestasis of pregnancy

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dc.authorscopusid25030403300
dc.authorscopusid37080733400
dc.authorscopusid57197941951
dc.authorscopusid56429760000
dc.authorscopusid12243344000
dc.authorscopusid35098173900
dc.authorscopusid36009433000
dc.contributor.authorÇifçi, S.
dc.contributor.authorIrak, K.
dc.contributor.authorBayram, M.
dc.contributor.authorEkmen, Nergiz
dc.contributor.authorKazezoglu, C.
dc.contributor.authorAcar, Zeynep
dc.contributor.authorSasani, Hadi
dc.date.accessioned2022-05-11T14:05:07Z
dc.date.available2022-05-11T14:05:07Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyoloji Ana Bilim Dalı
dc.description.abstractObjective: Intrahepatic cholestasis of pregnancy is a temporary, pregnancy-specific disease that resolves with delivery, characterized by itching (pruritus), as well as high transaminase and serum bile acid levels in the third trimester of pregnancy. Due to the effects of Autotaxin on the physiology of pregnancy, we aimed to investigate Autotaxin activity in patients with intrahepatic cholestasis of pregnancy. Patients and methods: Sixty-nine patients diagnosed with intrahepatic cholestasis of pregnancy and 20 healthy pregnant women were enrolled in the study. Fasting serum bile acid, pruritus intensity, serum parameters, gestational week of the patients at the time of diagnosis were recorded, and birth week and birth weight were monitored. Autotaxin serum level was measured enzymatically. Results: The mean serum bile acid level (n = 69; 38.74 ± 35.92 ?mol/L) in patients with intrahepatic cholestasis of pregnancy (n = 69) was detected to be higher than healthy pregnant women (n = 20; 5.05 ± 1.88 ?mol/L) (p < 0.001). Weak correlation was detected between serum bile acid level and itch intensity (p = 0.014, r = 0.295), while no relation was detected between Autotaxin and itch intensity (p = 0.446, r = 0.09). Although mean Autotaxin (intrahepatic cholestasis of pregnancy: 678.10 ± 424.42 pg/mL, control: 535.16 ± 256.47 pg/mL) levels were high in patients with intrahepatic cholestasis of pregnancy, it was not statistically significant (p = 0.157). Conclusion: In our study, we observed that the serum Autotaxin level did not make a significant difference in patients with intrahepatic cholestasis of pregnancy compared to healthy pregnant women. These findings suggest that larger clinical studies are required to reveal the physio-pathological effects of Autotaxin on pregnancy. © 2020 Elsevier España, S.L.U.
dc.description.sponsorshipWe thank the patients and Department of Gastroenterology. S.C. participated in the study design, acquisition of the data, data analysis and interpretation of the data and wrote the manuscript. N.E. participated in the data analysis and interpretation of the data and wrote the manuscript. M.B. K.I. C.K. and Z.A. performed the measurements and acquisition of the data.
dc.identifier.doi10.1016/j.gastrohep.2020.08.001
dc.identifier.endpage102
dc.identifier.issn0210-5705
dc.identifier.issue2en_US
dc.identifier.pmid33010963
dc.identifier.scopus2-s2.0-85092147734
dc.identifier.scopusqualityQ3
dc.identifier.startpage96
dc.identifier.urihttps://doi.org/10.1016/j.gastrohep.2020.08.001
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4898
dc.identifier.volume44
dc.identifier.wosWOS:000629642700002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSasani, Hadi
dc.language.isoen
dc.publisherEdiciones Doyma, S.L.
dc.relation.ispartofGastroenterologia y Hepatologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAutotaxin
dc.subjectIntrahepatic cholestasis
dc.subjectPregnancy
dc.subjectPruritus
dc.subjectalanine aminotransferase
dc.subjectaspartate aminotransferase
dc.subjectautotaxin
dc.subjectbile acid
dc.subjectbilirubin
dc.subjectalkylglycerophosphoethanolamine phosphodiesterase
dc.subjectphosphodiesterase
dc.subjectadult
dc.subjectalanine aminotransferase blood level
dc.subjectArticle
dc.subjectaspartate aminotransferase blood level
dc.subjectbile acid blood level
dc.subjectbilirubin blood level
dc.subjectbirth weight
dc.subjectcontrolled study
dc.subjectdisease association
dc.subjectdisease severity
dc.subjectenzyme activity
dc.subjectenzyme blood level
dc.subjectfemale
dc.subjectgestational age
dc.subjecthuman
dc.subjectintrahepatic cholestasis
dc.subjectintrahepatic cholestasis of pregnancy
dc.subjectmajor clinical study
dc.subjectpregnancy complication
dc.subjectpregnant woman
dc.subjectpruritus
dc.subjectblood
dc.subjectcomplication
dc.subjectintrahepatic cholestasis
dc.subjectpregnancy
dc.subjectpregnancy complication
dc.subjectprospective study
dc.subjectpruritus
dc.subjectAdult
dc.subjectCholestasis, Intrahepatic
dc.subjectFemale
dc.subjectHumans
dc.subjectPhosphoric Diester Hydrolases
dc.subjectPregnancy
dc.subjectPregnancy Complications
dc.subjectProspective Studies
dc.subjectPruritus
dc.titleRelationship between pruritus and autotaxin in intrahepatic cholestasis of pregnancy
dc.title.alternativeRelación entre el prurito y la autotaxina en la colestasis intrahepática del embarazo]
dc.typeArticle

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