Relationship between pruritus and autotaxin in intrahepatic cholestasis of pregnancy
Yükleniyor...
Dosyalar
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Ediciones Doyma, S.L.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: Intrahepatic cholestasis of pregnancy is a temporary, pregnancy-specific disease that resolves with delivery, characterized by itching (pruritus), as well as high transaminase and serum bile acid levels in the third trimester of pregnancy. Due to the effects of Autotaxin on the physiology of pregnancy, we aimed to investigate Autotaxin activity in patients with intrahepatic cholestasis of pregnancy. Patients and methods: Sixty-nine patients diagnosed with intrahepatic cholestasis of pregnancy and 20 healthy pregnant women were enrolled in the study. Fasting serum bile acid, pruritus intensity, serum parameters, gestational week of the patients at the time of diagnosis were recorded, and birth week and birth weight were monitored. Autotaxin serum level was measured enzymatically. Results: The mean serum bile acid level (n = 69; 38.74 ± 35.92 ?mol/L) in patients with intrahepatic cholestasis of pregnancy (n = 69) was detected to be higher than healthy pregnant women (n = 20; 5.05 ± 1.88 ?mol/L) (p < 0.001). Weak correlation was detected between serum bile acid level and itch intensity (p = 0.014, r = 0.295), while no relation was detected between Autotaxin and itch intensity (p = 0.446, r = 0.09). Although mean Autotaxin (intrahepatic cholestasis of pregnancy: 678.10 ± 424.42 pg/mL, control: 535.16 ± 256.47 pg/mL) levels were high in patients with intrahepatic cholestasis of pregnancy, it was not statistically significant (p = 0.157). Conclusion: In our study, we observed that the serum Autotaxin level did not make a significant difference in patients with intrahepatic cholestasis of pregnancy compared to healthy pregnant women. These findings suggest that larger clinical studies are required to reveal the physio-pathological effects of Autotaxin on pregnancy. © 2020 Elsevier España, S.L.U.
Açıklama
Anahtar Kelimeler
Autotaxin, Intrahepatic cholestasis, Pregnancy, Pruritus, alanine aminotransferase, aspartate aminotransferase, autotaxin, bile acid, bilirubin, alkylglycerophosphoethanolamine phosphodiesterase, phosphodiesterase, adult, alanine aminotransferase blood level, Article, aspartate aminotransferase blood level, bile acid blood level, bilirubin blood level, birth weight, controlled study, disease association, disease severity, enzyme activity, enzyme blood level, female, gestational age, human, intrahepatic cholestasis, intrahepatic cholestasis of pregnancy, major clinical study, pregnancy complication, pregnant woman, pruritus, blood, complication, intrahepatic cholestasis, pregnancy, pregnancy complication, prospective study, pruritus, Adult, Cholestasis, Intrahepatic, Female, Humans, Phosphoric Diester Hydrolases, Pregnancy, Pregnancy Complications, Prospective Studies, Pruritus
Kaynak
Gastroenterologia y Hepatologia
WoS Q Değeri
Q2
Scopus Q Değeri
Q3
Cilt
44
Sayı
2
