Administration of perivascular cyanoacrylate for the prevention of cellular damage in saphenous vein grafts: an experimental model

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dc.authorid0000-0003-0900-8140
dc.authorid0000-0001-5933-9322
dc.authorid0000-0002-1503-329X
dc.authorid0000-0001-9343-0947
dc.authorid0000-0002-3666-8673
dc.authorscopusid26666062100
dc.authorscopusid23391660500
dc.authorscopusid55120545200
dc.authorscopusid57190296887
dc.authorscopusid55621599800
dc.authorscopusid54788377700
dc.authorscopusid24437135100
dc.authorwosidtaner, temmuz/Q-3082-2016
dc.authorwosidÖzsin, Kadir Kaan/O-8581-2019
dc.authorwosidKAHRAMAN, Nail/C-6828-2019
dc.authorwosidYumun, Gunduz/M-1768-2015
dc.contributor.authorKahraman, Nail
dc.contributor.authorYümün, Gündüz
dc.contributor.authorGücü, Arif
dc.contributor.authorÖzsin, Kadir Kagan
dc.contributor.authorTaner, Temmuz
dc.contributor.authorŞener, Ebru
dc.contributor.authorGoncu, Mehmet Tugrul
dc.date.accessioned2022-05-11T14:36:00Z
dc.date.available2022-05-11T14:36:00Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kalp ve Damar Cerrahisi Ana Bilim Dalı
dc.description.abstractObjective: The saphenous vein is the most commonly used graft in coronary artery bypass surgery, since no suitable arterial graft is available. However, the frequency of late graft failure is a cause for research into graft protection. The objective of this study was to investigate the effect of synthetic adhesive cyanoacrylate administration on the saphenous vein graft for preventing vascular damage due to internal pressure on the graft. Methods: In this study we enrolled 20 volunteer subjects who had undergone coronary artery bypass surgery and who had excess saphenous vein grafts. Perivascular cyanoacrylate was administered to one of two saphenous vein grafts explanted from each patient. The other saphenous vein graft from each patient was not treated and was used as the control. A model of the arterial system was created using a saphenous vein cardiopulmonary bypass system. Circulation was maintained at 120 mmHg for 45 minutes. Afterwards, the grafts were subjected to histopathological examination. Results: The cyanoacrylate group of grafts did not develop severe vascular damage compared with many instances of moderate and severe damage due to compression in the control group of grafts (p = 0.003). Conclusion: Perivascular administration of cyanoacrylate appeared to be successful in the prevention of early saphenous vein graft injury. No in vivo study has been performed to date to assess endothelial damage in the saphenous vein, in order to demonstrate the long-term effect of cyanoacrylate. Further investigations are needed in this regard.
dc.identifier.doi10.5830/CVJA-2015-078
dc.identifier.endpage163
dc.identifier.issn1995-1892
dc.identifier.issn1680-0745
dc.identifier.issue3en_US
dc.identifier.pmid26506883
dc.identifier.scopus2-s2.0-84979018856
dc.identifier.scopusqualityQ3
dc.identifier.startpage159
dc.identifier.urihttps://doi.org/10.5830/CVJA-2015-078
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8331
dc.identifier.volume27
dc.identifier.wosWOS:000384800800013
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYümün, Gündüz
dc.language.isoen
dc.publisherClinics Cardive Publ Pty Ltd
dc.relation.ispartofCardiovascular Journal of Africa
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcyanoacrylate
dc.subjectsaphenous vein graft
dc.subjectvascular damage
dc.subjectarterial pressure
dc.subjectFibrin Glue
dc.subjectPerivenous Application
dc.subjectNeointima Formation
dc.subjectExternal Sheath
dc.subjectDisease
dc.subjectInjury
dc.subjectPolyglactin
dc.subjectExpression
dc.subjectStent
dc.titleAdministration of perivascular cyanoacrylate for the prevention of cellular damage in saphenous vein grafts: an experimental model
dc.typeArticle

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