Administration of perivascular cyanoacrylate for the prevention of cellular damage in saphenous vein grafts: an experimental model
Yükleniyor...
Dosyalar
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Clinics Cardive Publ Pty Ltd
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: The saphenous vein is the most commonly used graft in coronary artery bypass surgery, since no suitable arterial graft is available. However, the frequency of late graft failure is a cause for research into graft protection. The objective of this study was to investigate the effect of synthetic adhesive cyanoacrylate administration on the saphenous vein graft for preventing vascular damage due to internal pressure on the graft. Methods: In this study we enrolled 20 volunteer subjects who had undergone coronary artery bypass surgery and who had excess saphenous vein grafts. Perivascular cyanoacrylate was administered to one of two saphenous vein grafts explanted from each patient. The other saphenous vein graft from each patient was not treated and was used as the control. A model of the arterial system was created using a saphenous vein cardiopulmonary bypass system. Circulation was maintained at 120 mmHg for 45 minutes. Afterwards, the grafts were subjected to histopathological examination. Results: The cyanoacrylate group of grafts did not develop severe vascular damage compared with many instances of moderate and severe damage due to compression in the control group of grafts (p = 0.003). Conclusion: Perivascular administration of cyanoacrylate appeared to be successful in the prevention of early saphenous vein graft injury. No in vivo study has been performed to date to assess endothelial damage in the saphenous vein, in order to demonstrate the long-term effect of cyanoacrylate. Further investigations are needed in this regard.
Açıklama
Anahtar Kelimeler
cyanoacrylate, saphenous vein graft, vascular damage, arterial pressure, Fibrin Glue, Perivenous Application, Neointima Formation, External Sheath, Disease, Injury, Polyglactin, Expression, Stent
Kaynak
Cardiovascular Journal of Africa
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
27
Sayı
3
