A new impedimetric biosensor utilizing VEGF receptor-1 (Flt-1): Early diagnosis of vascular endothelial growth factor in breast cancer

Basit Öğe Kaydı
dc.authorscopusid6506764918
dc.authorwosidSezgintürk, Mustafa Kemal/AAY-1439-2021
dc.contributor.authorSezgintürk, Mustafa Kemal
dc.date.accessioned2022-05-11T14:29:43Z
dc.date.available2022-05-11T14:29:43Z
dc.date.issued2011
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractA new impedimetric biosensor, based on the use of vascular endothelial growth factor receptor-1 (VEGF-R1), was developed for the determination of vascular endothelial growth factor (VEGF). VEGF-R1 was immobilized through covalent coupling with 3-mercaptopropionic acid which formed a self-assembled monolayer on gold electrodes. Cyclic voltammetry (CV) and electrochemical impedance spectroscopy techniques were employed to characterize the immobilization process and to detect VEGF. To successfully construct the biosensor current, experimental parameters were optimized. Kramers-Kronig Transform was performed on the experimental impedance data. The obtained results provided a linear response range from 10 to 70 pg/mL human VEGF. The applicability of the developed biosensor in the determination of VEGF in a spiked artificial human serum sample was experienced, yielding average recovery of 101%, in that order, with an average relative deviation value less than 5%. (C) 2011 Elsevier B.V. All rights reserved.
dc.description.sponsorshipTUBITAK (The Scientific and Technological Research Council of Turkey)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [109T 172]
dc.description.sponsorshipI gratefully acknowledge the financial support of TUBITAK (The Scientific and Technological Research Council of Turkey. Project number: 109T 172).
dc.identifier.doi10.1016/j.bios.2011.03.025
dc.identifier.endpage4039
dc.identifier.issn0956-5663
dc.identifier.issn1873-4235
dc.identifier.issue10en_US
dc.identifier.pmid21515041
dc.identifier.scopus2-s2.0-79956366825
dc.identifier.scopusqualityQ1
dc.identifier.startpage4032
dc.identifier.urihttps://doi.org/10.1016/j.bios.2011.03.025
dc.identifier.urihttps://hdl.handle.net/20.500.11776/7109
dc.identifier.volume26
dc.identifier.wosWOS:000291904000009
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSezgintürk, Mustafa Kemal
dc.language.isoen
dc.publisherElsevier Advanced Technology
dc.relation.ispartofBiosensors & Bioelectronics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectVEGF-R1
dc.subjectVEGF
dc.subjectBreast cancer
dc.subjectElectrochemical impedance spectroscopy
dc.subjectBiosensor
dc.subjectBiomarker
dc.subjectDispersion
dc.titleA new impedimetric biosensor utilizing VEGF receptor-1 (Flt-1): Early diagnosis of vascular endothelial growth factor in breast cancer
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
7109.pdf
Boyut:
665.17 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Fen Edebiyat Fakültesi Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu