Protective Effect of Quercetin Against Renal Toxicity Induced by Cadmium in Rats

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dc.authorscopusid13609545500
dc.authorscopusid7006356462
dc.authorscopusid8583021500
dc.authorscopusid24436194200
dc.authorscopusid36023238400
dc.authorscopusid7801455897
dc.authorwosidAktas, Cevat/D-8468-2011
dc.contributor.authorAktoz, Tevfik
dc.contributor.authorKanter, Mehmet
dc.contributor.authorUz, Yesim Hulya
dc.contributor.authorAktaş, Cevat
dc.contributor.authorErboğa, Mustafa
dc.contributor.authorAtakan, İrfan Hüseyin
dc.date.accessioned2022-05-11T14:41:26Z
dc.date.available2022-05-11T14:41:26Z
dc.date.issued2012
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractObjective: The aim of the present study was to examine the protective effect of quercetine (QE) against cadmium (Cd)-induced renal toxicity. Material and Methods: A total of 24 male Wistar albino rats were divided into three groups: control, Cd-treated and Cd-treated with QE; each group containing 8 animals. The Cd-treated group was injected subcutaneously with CdCl2 dissolved in saline in the dose of 2 ml/kg/day for 30 days, resulting in a dosage of 1 mg/kg Cd. The rats in the QE treated groups were given QE (15 mg/kg body weight) once a day intraperitoneally starting 2 days prior to Cd injection during the study period. Results: The renal histology in Cd-treated rats showed mesangial expansion, thickening of capsular basement membranes, glomerular basement membranes and tubular basement membranes, characterized by an increase in periodic acid Schiff (PAS)-positive areas as compared with control animals. With the QE treatment, despite the presence of only a few swollen glomeruli, we noticed a marked protection of renal structure when compared with the Cd-treated rats. Furthermore, QE pretreatment resulted in increased proliferating cell nuclear antigen (PCNA) immunoreactivity and decreased the activity of Terminal Transferase dUTP Nick End Labeling (TUNEL). Conclusion: These findings suggest that QE may attenuate Cd-induced renal toxicity.
dc.identifier.doi10.5152/balkanmedj.2011.014
dc.identifier.endpage61
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84862067233
dc.identifier.scopusqualityQ3
dc.identifier.startpage56
dc.identifier.urihttps://doi.org/10.5152/balkanmedj.2011.014
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9179
dc.identifier.volume29
dc.identifier.wosWOS:000303618400011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorAktaş, Cevat
dc.language.isoen
dc.publisherGalenos Publ House
dc.relation.ispartofBalkan Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCadmium
dc.subjectimmunohistochemistry
dc.subjectquercetin
dc.subjectrenal toxicity
dc.subjectTUNEL
dc.subjectLipid-Peroxidation
dc.subjectUltrastructural-Changes
dc.subjectCell-Death
dc.subjectKidney
dc.subjectNephrotoxicity
dc.subjectIntoxication
dc.subjectExposure
dc.subjectSelenium
dc.subjectMetallothionein
dc.subjectRegeneration
dc.titleProtective Effect of Quercetin Against Renal Toxicity Induced by Cadmium in Rats
dc.typeArticle

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