Structural characterization and biological evaluation of antimony(III) and bismuth(III) complexes with imidazolidine-2-thione
Yükleniyor...
Dosyalar
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier B.V.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
There is an emerging interest in the synthesis of antimony(III) and bismuth(III) complexes with sulfur containing ligands, this has been attributed to their wide structural diversity and their interesting application as biological agents. In the present work, four new antimony(III) and bismuth(III) complexes {[SbCl(IMT)3(?-Cl)SbCl3(?-Cl)]n} (1), {[SbBr2(IMT)2(?-Br)]n} (2), {[BiBr2(IMT)2(?-Br)]n} (3), and {mer-[BiI3(IMT)3]} (4) with imidazolidine-2-thione (IMT) have been prepared and characterized structurally, spectroscopically, and thermogravimetrically. The crystal structures of 1-4 have been determined by single-crystal X-ray diffraction. Complex 1 is the first structural example of polymeric antimony(III) chloride thioamide complex containing two different metallic centers. Complexes 2 and 3 are isostructural and the central atoms are six-coordinate in a distorted octahedral geometry with the zigzag chains formed by corner-sharing octahedra. Complex 4 is an example of neutral mononuclear bismuth(III) iodide complex with octahedral geometry. Complexes 1-4 have been evaluated for in vitro cytotoxic activity against human breast adenocarcinoma (MCF-7) cells. Complexes 1-4 appeared to show low cytotoxic activity against MCF-7 cells. The toxicity of 1-4 has been evaluated on normal human fetal lung fibroblast cells (MRC-5). The toxicity of antimony compounds 1-2 was greater than that of bismuth compounds 3-4. The influence of 1-4, on the catalytic peroxidation of the linoleic acid by the enzyme lipoxygenase (LOX) has been determined experimentally. © 2021
Açıklama
Anahtar Kelimeler
Antimony(III) complexes, Biological activity, Bismuth(III) complexes, Imidazolidine-2-thione, Structural characterization, Antimony compounds, Bismuth compounds, Cell culture, Chlorine compounds, Linoleic acid, Single crystals, Synthesis (chemical), Toxicity, Antimony(III), Antimony(III) complex, Bismuth(III), Bismuth(III) complex, Complex 1, Imidazolidine-2-thione, MCF-7 cells, Octahedral geometry, Structural characterization, Thiones, Bioactivity
Kaynak
Journal of Molecular Structure
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
1235