Effect of hesperetin on systemic inflammation and hepatic injury after blunt chest trauma in rats

Basit Öğe Kaydı
dc.authorscopusid57212512972
dc.authorscopusid55838809000
dc.contributor.authorDuran, Y.
dc.contributor.authorKaraboğa, İhsan
dc.date.accessioned2022-05-11T14:02:59Z
dc.date.available2022-05-11T14:02:59Z
dc.date.issued2020
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.departmentYüksekokullar, Sağlık Yüksekokulu, Acil Yardım ve Afet Yönetimi Bölümü
dc.description.abstractWe investigated the protective effect of hesperetin on hepatic damage after blunt chest trauma in rats using histological and biochemical methods. We used 18 adult male rats in three groups of six: control, chest trauma and chest trauma + hesperetin. Chest trauma was caused by dropping a metal cylinder onto the right hemithorax. Hesperetin, 100 mg/kg, was administered orally for 7 days. At the end of the seventh day, liver tissue samples were obtained. Serum tumor necrosis factor-alpha (TNF-?), interleukin 1-beta (IL-1?), alanine aminotransferase (AST), aspartate transferase (ALT) and lactate dehydrogenase (LDH) enzyme activities were measured in blood samples taken from the heart. The general structure of liver tissue was investigated using hematoxylin and eosin staining. Nuclear factor kappa beta (Nf-??) expression in liver tissue was determined by the indirect immunohistochemical method. Apoptosis was determined using the terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) method. Decreased TNF-?, AST and ALT enzyme activity, fewer histopathological changes and lower Nf-kB expression were observed in the hesperetin treated group compared to the chest trauma group. We also found reduced hepatic apoptosis in the chest trauma + hesperetin group compared to the chest trauma group. Hesperetine inhibits liver damage by reducing proinflammatory cytokines and by suppressing Nf-?? activity in a blunt chest trauma model in rats. © 2019, © 2019 The Biological Stain Commission.
dc.identifier.doi10.1080/10520295.2019.1691265
dc.identifier.endpage304
dc.identifier.issn1052-0295
dc.identifier.issue4en_US
dc.identifier.pmid31850807
dc.identifier.scopus2-s2.0-85076903052
dc.identifier.scopusqualityQ2
dc.identifier.startpage297
dc.identifier.urihttps://doi.org/10.1080/10520295.2019.1691265
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4561
dc.identifier.volume95
dc.identifier.wosWOS:000503525900001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDuran, Y.
dc.institutionauthorKaraboğa, İhsan
dc.language.isoen
dc.publisherTaylor and Francis Ltd
dc.relation.ispartofBiotechnic and Histochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectapoptosis
dc.subjectchest
dc.subjecthesperetin
dc.subjectliver injury
dc.subjectNf-??
dc.subjectrats
dc.subjectTNF-?
dc.subjecttrauma
dc.subjecthesperetin
dc.subjecthesperidin
dc.subjectanimal
dc.subjectapoptosis
dc.subjectinflammation
dc.subjectinjury
dc.subjectliver
dc.subjectliver disease
dc.subjectpathology
dc.subjectrat
dc.subjectAnimals
dc.subjectApoptosis
dc.subjectHesperidin
dc.subjectInflammation
dc.subjectLiver
dc.subjectLiver Diseases
dc.subjectRats
dc.subjectWounds and Injuries
dc.titleEffect of hesperetin on systemic inflammation and hepatic injury after blunt chest trauma in rats
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
4561.pdf
Boyut:
1.99 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Sağlık Yüksekokulu Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu