Functional roles of angiogenic factors and receptors on non-endothelial cells in the oropharyngeal cavity of the chukar partridge (Alectoris chukar)

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dc.authorscopusid56521500300
dc.authorscopusid9842574500
dc.authorscopusid36650778800
dc.authorwosidErdogan, Serkan/F-5923-2011
dc.contributor.authorSağsöz, Hakan
dc.contributor.authorGüney Saruhan, Berna
dc.contributor.authorErdoğan, Serkan
dc.date.accessioned2022-05-11T14:42:24Z
dc.date.available2022-05-11T14:42:24Z
dc.date.issued2017
dc.departmentFakülteler, Veteriner Fakültesi, Temel Bilimler Bölümü, Anatomi Ana Bilim Dalı
dc.description.abstractThe vascular endothelial growth factor (VEGF) family belong to the platelet-derived growth factor supergene family and is involved in angiogenesis and mitogenesis. The VEGF-VEGFR system regulates endothelial cell proliferation, migration, vascular permeability, secretion and other non-endothelial cells functions. To clarify the possible role of endothelial and non-endothelial cells, VEGF and its receptors, vascular endothelial cell growth inhibitor (VEGI) were immunohistochemically examined in oropharyngeal organs. Ten adult partridges were used in this study and the pharynx and larynx were dissected together with the palate and tongue. VEGI, VEGF and its receptor were highly expressed in luminal epithelial and stromal cells, when compared to glandular epithelial and muscle cells (P<0.05). Moreover, VEGF, its receptors and VEGI were expressed rather strongly in the endothelial cells of the blood capillaries and in both the endothelial and smooth muscle cells of the large and small blood vessels. In conclusion, VEGF and its receptors (flt1/fms, flk1/KDR and flt4) and VEGI were expressed by various cell groups at varying intensity in the oropharyngeal organs. This demonstrates that they play a critical role in the regulation and maintenance of the functions in cells different from endothelial ones as well as in cell proliferation, differentiation, apoptosis and angiogenesis.
dc.identifier.doi10.1111/azo.12149
dc.identifier.endpage55
dc.identifier.issn0001-7272
dc.identifier.issn1463-6395
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84949516379
dc.identifier.scopusqualityQ2
dc.identifier.startpage44
dc.identifier.urihttps://doi.org/10.1111/azo.12149
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9364
dc.identifier.volume98
dc.identifier.wosWOS:000392846400006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorErdoğan, Serkan
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofActa Zoologica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectbird
dc.subjectimmunohistochemistry
dc.subjectpalate
dc.subjecttongue
dc.subjectVEGF-VEGFR system
dc.subjectGrowth-Factor Vegf
dc.subjectInhibitor Vegi
dc.subjectOral-Tissues
dc.subjectExpression
dc.subjectCarcinomas
dc.subjectAutocrine
dc.subjectDensity
dc.subjectTongue
dc.subjectCancer
dc.titleFunctional roles of angiogenic factors and receptors on non-endothelial cells in the oropharyngeal cavity of the chukar partridge (Alectoris chukar)
dc.typeArticle

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