Investigation of hepatoprotective effect of some algae species on carbon tetrachloride-induced liver injury in rats

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dc.authorscopusid56951315900
dc.authorscopusid57190766109
dc.authorscopusid9733909000
dc.authorscopusid57200049871
dc.authorscopusid57212510531
dc.authorscopusid55897696600
dc.contributor.authorAltinok-Yipel, F.
dc.contributor.authorTekeli, İbrahim Özan
dc.contributor.authorÖzsoy, S.Y.
dc.contributor.authorGüvenç, M.
dc.contributor.authorSayin, S.
dc.contributor.authorYipel, Mustafa
dc.date.accessioned2022-05-11T14:02:53Z
dc.date.available2022-05-11T14:02:53Z
dc.date.issued2020
dc.departmentFakülteler, Veteriner Fakültesi, Klinik Bilimler Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Veteriner Fakültesi, Klinik Öncesi Bilimler Bölümü, Farmakoloji ve Toksikoloji Ana Bilim Dalı
dc.description.abstractThe aim of this study was to investigate hepatoprotective effect of some algae species such as Spirulina platensis, Chlorella vulgaris, Laminaria japonica, Sargassum sp. on experimental acute hepatotoxicity model that induced with carbon tetrachloride (CCl4) in rats. Algaes at a dose of 200 mg/kg and Silymarin at a dose of 25 mg/kg were orally administered for 7 days followed by CCl4 at a single dose (0.5 ml/kg), at the 8th day to cause experimental acute hepatotoxicity. Levels of biochemical (AST, ALT etc.), lipid peroxidation (MDA), antioxidant (GSH, CAT, GPx) parameters and histopathological examination were carried out to investigate the hepatoprotective effects of algae. In Sp group ALT and ALP levels were significantly decreased compared with CCl4 (p <.05). Histological liver structures of Sp group were similar to the control group. MDA, GPx and CAT levels of Sp and La groups were significantly different compared with CCl4 (p <.05). Based on these results, algae species able to minimise the toxic effects of CCl4 and especially S. platensis could be used in the purpose of protection against chemical-induced hepatotoxicity. © 2019 Informa UK Limited, trading as Taylor & Francis Group.
dc.description.sponsorshipMustafa Kemal Üniversitesi
dc.description.sponsorshipThis work was financially supported by Scientific Research Projects Coordination of Mustafa Kemal University (Project no:14660).
dc.identifier.doi10.1080/13813455.2019.1702062
dc.identifier.endpage467
dc.identifier.issn1381-3455
dc.identifier.issue5en_US
dc.identifier.pmid31855071
dc.identifier.scopus2-s2.0-85076934247
dc.identifier.scopusqualityQ2
dc.identifier.startpage463
dc.identifier.urihttps://doi.org/10.1080/13813455.2019.1702062
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4526
dc.identifier.volume126
dc.identifier.wosWOS:000503535000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAltınok Yipel, Fulya|Yipel, Mustafa
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.relation.ispartofArchives of Physiology and Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAlgae
dc.subjectcarbon tetrachloride
dc.subjecthepatoprotective effect
dc.subjectoxidative stress
dc.subjectantioxidant
dc.subjectcarbon tetrachloride
dc.subjectplant extract
dc.subjectprotective agent
dc.subjectanimal
dc.subjectchemistry
dc.subjectChlorella vulgaris
dc.subjectdrug effect
dc.subjectlipid peroxidation
dc.subjectliver
dc.subjectmale
dc.subjectmetabolism
dc.subjectoxidative stress
dc.subjectpathology
dc.subjectphytotherapy
dc.subjectrat
dc.subjecttoxic hepatitis
dc.subjectWistar rat
dc.subjectAnimals
dc.subjectAntioxidants
dc.subjectCarbon Tetrachloride
dc.subjectChemical and Drug Induced Liver Injury, Chronic
dc.subjectChlorella vulgaris
dc.subjectLipid Peroxidation
dc.subjectLiver
dc.subjectMale
dc.subjectOxidative Stress
dc.subjectPhytotherapy
dc.subjectPlant Extracts
dc.subjectProtective Agents
dc.subjectRats
dc.subjectRats, Wistar
dc.titleInvestigation of hepatoprotective effect of some algae species on carbon tetrachloride-induced liver injury in rats
dc.typeArticle

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