Voltammetric behavior of lercanidipine and anodic adsorptive stripping voltammetric method for assay in pharmaceutical dosage forms and biological fluids

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dc.authorid0000-0003-4214-1744
dc.authorscopusid25422504200
dc.authorscopusid57204809386
dc.authorscopusid7006065730
dc.authorwosidOzturk, funda/G-9435-2014
dc.authorwosidZeybek, Derya Koyuncu/AAA-8451-2021
dc.contributor.authorÖztürk, Funda
dc.contributor.authorZeybek, D. Koyuncu
dc.contributor.authorKılıç, E.
dc.date.accessioned2022-05-11T14:29:57Z
dc.date.available2022-05-11T14:29:57Z
dc.date.issued2014
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractElectrochemistry of lercanidipine (LCN) was investigated and its optimal conditions were evaluated based on the irreversible and diffusion-controlled electrochemical oxidation signal (+ 0.93 V) of a carbon paste electrode (CPE) versus Ag/AgCl in Britton Robinson buffer (BR) and ethanol mixture of pH 4.5. Electrochemical determination was performed by square wave anodic adsorptive stripping voltammetry (SWAAdSV). Linear range was found to be between 3.3 x 10(-7) mol L-1 and 4.5 x 10(-5) mol L-1 in two different regions; preconcentration potential and time were found to be 0.0 V and 150 s, respectively. In this method, the limit of quantification (LOQ) was found to be 2.0 x 10(-8) mol L-1 (0.012 mg L-1). The method was applied to determine the content of LCN in a commercial pharmaceutical preparation, spiked human serum and spiked human urine. The method was found to be highly accurate and precise, having a relative standard deviation of less than 10% for all applications.
dc.identifier.endpage770
dc.identifier.issn0324-1130
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84936752787
dc.identifier.scopusqualityN/A
dc.identifier.startpage764
dc.identifier.urihttps://hdl.handle.net/20.500.11776/7184
dc.identifier.volume46
dc.identifier.wosWOS:000348242400014
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorÖztürk, Funda
dc.language.isoen
dc.publisherBulgarian Acad Science
dc.relation.ispartofBulgarian Chemical Communications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCarbon paste electrode
dc.subjecthuman urine
dc.subjecthuman serum
dc.subjectlercanidipine
dc.subjectpharmaceuticals
dc.subjectFormulations
dc.titleVoltammetric behavior of lercanidipine and anodic adsorptive stripping voltammetric method for assay in pharmaceutical dosage forms and biological fluids
dc.typeArticle

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