The role of COL6A1and PD-1 expressions in renal cell carcinoma

Basit Öğe Kaydı
dc.authorscopusid55655819700
dc.authorscopusid57218104783
dc.authorscopusid6701432632
dc.authorscopusid55799070700
dc.authorscopusid57210859841
dc.authorscopusid6507796024
dc.authorscopusid56461231100
dc.contributor.authorKarabulut, Yasemin Yuyucu
dc.contributor.authorKöse, Emre Cagatay
dc.contributor.authorBozlu, Murat
dc.contributor.authorTuncel, Ferah
dc.contributor.authorYüksek, Gui Emek
dc.contributor.authorEtit, Demet
dc.contributor.authorAkbay, Erdem
dc.contributor.authorÖznur, Meltem
dc.date.accessioned2022-05-11T14:36:55Z
dc.date.available2022-05-11T14:36:55Z
dc.date.issued2020
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.description.abstractObjective: The COL6A1 is a gene encoding the alpha 1 polypeptide subunit of collagen 6 (COL6A1), an extracellular matrix protein subunit. Programmed cell death receptor-1 (PD-1) and its ligand, programmed cell death receptor ligand-1 (PD-L1) have been shown to have a prognostic significance in clear cell renal cell carcinomas (RCCs). In this study, we evaluated the expressions of COL6A1 and PD-1 in four different RCC subtypes. Materials and methods: A total of 161 radical nephrectomy and nephron-sparing surgery cases with Ra7s from five different health care centers were included in this study. Clinical data of the cases were taken from electronic records of the institutions. The pathological data were collected by an expert uropathologist and re-evaluated with slides obtained from paraffin blocks of the cases. The correlation of COL6A1 and PD-1 expression with sex, age, tumor type, lymphovascular invasion (LVI), World Health Organization/International Society of Urological Pathology (WHO/ISUP) grade, and tumor stage (pT) was analyzed with the Pearson chi-squared test. Results: Patients with sarcomatoid RCC and clear cell RCC had significantly higher COL6A1 scores and intensities than in other types of RCC (p=0.004 and p=0.002, respectively). WHO/ISUP grade and, COL6A1 and PD-1 staining scores also showed positive correlation (r=0.230, p=0.004 and r=0.277, p=0.001, respectively for COL6A1 and r=0.191, p=0.018 and r=0.166, p=0.041, respectively for PD-1). The staining scores and intensities of COL6A1 and PD-1 were not different between the patients with positive and negative LVI (p>0.05). Conclusion: In high-grade RCCs, we found the relationship between immunohistochemical staining scores of COL6A1 and PD-1 proteins and clinical, demographic, and histopathological parameters. Our results proved that COL6A1 and PD-1 are really promising proteins as prognostic parameters and for targeted immunotherapy.
dc.description.sponsorshipMersin UniversityMersin University [2017-2-AP3-2425]
dc.description.sponsorshipThe authors declared that this study has received Mersin University Scientific Research Projects project, AP3; 2017-2-AP3-2425 as financial support.
dc.identifier.doi10.5152/tud.2020.20062
dc.identifier.endpage287
dc.identifier.issn2149-3235
dc.identifier.issn2149-3057
dc.identifier.issue4en_US
dc.identifier.pmid32479254
dc.identifier.scopus2-s2.0-85087896380
dc.identifier.scopusqualityQ3
dc.identifier.startpage282
dc.identifier.urihttps://doi.org/10.5152/tud.2020.20062
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8484
dc.identifier.volume46
dc.identifier.wosWOS:000550781400015
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖznur, Meltem
dc.language.isoen
dc.publisherAves
dc.relation.ispartofTurkish Journal of Urology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectRenal cell carcinoma
dc.subjectCOL6A1
dc.subjectPD-1
dc.subjectPoor-Prognosis
dc.subjectSystem
dc.titleThe role of COL6A1and PD-1 expressions in renal cell carcinoma
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
8484.pdf
Boyut:
1.82 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu