Efficacy of Several Therapeutic Agents in a Murine Model of Dry Eye Syndrome

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dc.authorscopusid7006243697
dc.authorscopusid55316940600
dc.authorwosidKilic, Servet/ABA-3409-2020
dc.contributor.authorKılıç, Servet
dc.contributor.authorKulualp, Kadri
dc.date.accessioned2022-05-11T14:42:13Z
dc.date.available2022-05-11T14:42:13Z
dc.date.issued2016
dc.departmentFakülteler, Veteriner Fakültesi, Klinik Bilimler Bölümü, Cerrahi Ana Bilim Dalı
dc.description.abstractIn the current study, we used 56 female BALB/c mice with induced dry eye syndrome to evaluate the therapeutic effects of formal saline (FS), sodium hyaluronate (SH), diclofenac sodium (DS), olopatadine (OP), retinoic acid (RA), fluoromethanole (FML), cyclosporine A (CsA), and doxycycline hyclate (DH). All subjects were kept in an evaporative 'dry eye cabinet' for the assessment of blink rate, tear production, tear break-up time, and impression cytology prior to (baseline) and during weeks 2, 4, and 6 of the study. The right eyes of all subjects were treated topically with 5 AL of the test agent twice daily during weeks 2 through 6. Impression cytology and tear break-up time differed between time points in all groups and differed between groups at weeks 4 and 6. Blink rate differed by time point only in the FS, FML, and DH groups. Tear production according to the phenol red cotton thread test differed by time point for all groups except RA, CsA, and DH and differed between groups only at week 6. Among the compounds tested in the present study, DS and CsA were the most effective therapeutic agents in our mouse model of dry eye syndrome; these agents likely exert their therapeutic effect through their antiinflammatory activity.
dc.identifier.endpage118
dc.identifier.issn1532-0820
dc.identifier.issue2en_US
dc.identifier.pmid27053565
dc.identifier.scopus2-s2.0-84963946915
dc.identifier.scopusqualityQ2
dc.identifier.startpage112
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9285
dc.identifier.volume66
dc.identifier.wosWOS:000375350800005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKılıç, Servet
dc.language.isoen
dc.publisherAmer Assoc Laboratory Animal Science
dc.relation.ispartofComparative Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectOcular Surface
dc.subjectAntiinflammatory Therapy
dc.subjectTear Production
dc.subjectMouse Model
dc.subjectTopical Cyclosporine
dc.subjectKeratoconjunctivitis
dc.subjectPrevalence
dc.subjectFilm
dc.subjectSensitivity
dc.subjectManagement
dc.titleEfficacy of Several Therapeutic Agents in a Murine Model of Dry Eye Syndrome
dc.typeArticle

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