Effect of lifestyle modifications on diastolic functions and aortic stiffness in prehypertensive subjects: a prospective cohort study

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dc.authorscopusid6505680586
dc.authorscopusid55881189500
dc.authorscopusid37058172000
dc.authorscopusid16315021800
dc.authorscopusid26532378600
dc.authorscopusid55810763400
dc.authorwosidAlpsoy, Seref/Z-1808-2018
dc.contributor.authorAlpsoy, Şeref
dc.contributor.authorOran, Mustafa
dc.contributor.authorTopçu, Birol
dc.contributor.authorAkyüz, Aydın
dc.contributor.authorAkkoyun, Dursun Çayan
dc.contributor.authorDeğirmenci, Hasan
dc.date.accessioned2022-05-11T14:10:09Z
dc.date.available2022-05-11T14:10:09Z
dc.date.issued2013
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.description.abstractObjective: Prehypertension is one of the primary causes of major cardiovascular events independent from other cardiovascular risk factors. The aim of the study was to evaluate the effect of therapeutic lifestyle modifications (LSMs) on cardiac diastolic function and aortic stiffness in prehypertensive subjects. Methods: This study designed as a prospective cohort study. Sixty-one prehypertensive adults were included in this study. The goals of LMS were weight loss of at least 5 kg in subjects with a BMI >= 25 kg/m(2) and moderate-intensity physical activity at least 180 minutes per week. We evaluated left ventricular (LV) diastolic function and aortic stiffness parameters at baseline and after 6 months by conventional and tissue Doppler imaging (TDI) echocardiography. Statistical analyses were performed using Wilcoxon-signed rank test and the paired sample t test. Results: Transmitral early velocity (E), the ratio of E to transmitral late velocity (E/A), TDI diastolic early septal velocity (septal E), TDI systolic septal velocity (septal S), TDI early lateral velocity (lateral E), the ratio of septal E to TDI late septal (septal A) velocity (septal E/A) and the ratio of lateral E to late lateral (lateral A) velocity (lateral E/A) were found to be significantly increased after the LSMs (p<0.05 for all). The beta stiffness index was decreased (12.07 vs. 6.33; p < 0.001) and the aortic compliance (0.02 cm/mmHg vs. 0.05 cm/mmHg; p<0.001) and the aortic strain (3.28% vs. 7.02%; p<0.001) were increased significantly after the LSMs. Conclusion: LSMs improve conventional and TDI echocardiographic parameters and aortic stiffness measurements in subjects with prehypertension.
dc.identifier.doi10.5152/akd.2013.139
dc.identifier.endpage451
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue5en_US
dc.identifier.pmid23665986
dc.identifier.scopus2-s2.0-84881050623
dc.identifier.scopusqualityQ3
dc.identifier.startpage446
dc.identifier.urihttps://doi.org/10.5152/akd.2013.139
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5306
dc.identifier.volume13
dc.identifier.wosWOS:000323324400010
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAlpsoy, Şeref
dc.institutionauthorOran, Mustafa
dc.institutionauthorTopçu, Birol
dc.institutionauthorAkyüz, Aydın
dc.institutionauthorAkkoyun, Dursun Çayan
dc.institutionauthorDeğirmenci, Hasan
dc.language.isoen
dc.publisherAves
dc.relation.ispartofAnatolian Journal of Cardiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPrehypertension
dc.subjectDoppler echocardiography
dc.subjectaortic stiffness
dc.subjectlife change events
dc.subjectBlood-Pressure
dc.subjectArterial Stiffness
dc.subjectCardiovascular Risk
dc.subjectWeight-Reduction
dc.subjectHypertension
dc.subjectEvents
dc.titleEffect of lifestyle modifications on diastolic functions and aortic stiffness in prehypertensive subjects: a prospective cohort study
dc.title.alternativePrehipertansif bireylerde yaşam şekli de?i şikli?inin diyastolik fonksiyonlar ve aort sertli?i üzerine etkisi: Ileriye dönük bir kohort çali şma]
dc.typeArticle

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