Evaluation of the relationship between serum ghrelin levels and cancer cachexia in patients with locally advanced nonsmall-cell lung cancer treated with chemoradiotherapy

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dc.authorscopusid57078797800
dc.authorscopusid55256146300
dc.authorscopusid16643660500
dc.authorscopusid57196317856
dc.authorscopusid6506813723
dc.authorscopusid55357428000
dc.authorscopusid57208880300
dc.contributor.authorUysal, Pelin
dc.contributor.authorUsul Afşar, Çiğdem
dc.contributor.authorSözer, Volkan
dc.contributor.authorİnanç, Berrin
dc.contributor.authorAğaoğlu, Fulya
dc.contributor.authorGüral, Zeynep
dc.contributor.authorUzun, Hafize
dc.contributor.authorFazlıoğlu, Nevin
dc.date.accessioned2022-05-11T14:05:01Z
dc.date.available2022-05-11T14:05:01Z
dc.date.issued2020
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground: Ghrelin plays a role in mechanisms related to cancer progression - including cell proliferation, invasion and migration, and resistance to apoptosis in the cell lines from several cancers. We investigated the role of ghrelin levels in cancer cachexia-anorexia in patients with locally advanced nonsmall-cell lung cancer (NSCLC) treated with chemoradiotherapy (CRT). Materials and Methods: This study involved 84 NSCLC patients who had received concomitant CRT. Blood ghrelin levels were compared before and 3 months after CRT. Meanwhile, changes in body weight of the patients were also investigated with changes in ghrelin levels before and after CRT. Results: Ghrelin levels were significantly decreased in line with changes in patients' weights in patients receiving CRT (P < 0.001). Serum albumin levels and inflammatory-nutritional index were significantly decreased after radiotherapy (RT) (3.01 ± 0.40 g/dL, 0.38 ± 0.20) when compared with its baseline levels (3.40 ± 0.55 g/dL,P < 0.001; 0.86 ± 0.71,P < 0.001, respectively). Serum C-reactive protein levels were significantly increased after CRT (7.49 ± 6.53 mg/L) when compared with its baseline levels (9.54 ± 3.80 mg/L,P = 0.038). After RT, ghrelin levels in patients were positively correlated with body mass index (r = 0.830,P < 0.001) and albumin (r = 0.758,P < 0.001). Conclusion: Ghrelin may play a role in the pathogenesis of weight loss in NSCLC patients. Ghrelin seems to be implicated in cancer-related weight loss. Ghrelin, cancer, and RT all together have a role in tumor-related anorexia-cachexia in patients with NSCLC. Results of this study need further evaluation as regards to its potential role as an adjuvant diagnostic or prognostic marker. © 2020 Wolters Kluwer Medknow Publications. All rights reserved.
dc.identifier.doi10.4103/jcrt.JCRT_10_19
dc.identifier.endpage859
dc.identifier.issn0973-1482
dc.identifier.issue4en_US
dc.identifier.pmid32930130
dc.identifier.scopus2-s2.0-85091051199
dc.identifier.scopusqualityQ3
dc.identifier.startpage855
dc.identifier.urihttps://doi.org/10.4103/jcrt.JCRT_10_19
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4867
dc.identifier.volume16
dc.identifier.wosWOS:000585412200025
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorFazlıoğlu, Nevin
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofJournal of Cancer Research and Therapeutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCancer cachexia
dc.subjectchemoradiotherapy
dc.subjectghrelin
dc.subjectlocally advanced nonsmall cell lung cancer
dc.subjectalbumin
dc.subjectC reactive protein
dc.subjectcarboplatin
dc.subjectcisplatin
dc.subjectetoposide
dc.subjectghrelin
dc.subjectpaclitaxel
dc.subjectpemetrexed
dc.subjectvinblastine
dc.subjectC reactive protein
dc.subjectghrelin
dc.subjecthuman serum albumin
dc.subjectadult
dc.subjectadvanced cancer
dc.subjectaged
dc.subjectalbumin blood level
dc.subjectanorexia
dc.subjectArticle
dc.subjectblood sampling
dc.subjectbody mass
dc.subjectbody weight change
dc.subjectcachexia
dc.subjectcancer combination chemotherapy
dc.subjectcancer patient
dc.subjectcancer radiotherapy
dc.subjectchemoradiotherapy
dc.subjectfemale
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmultiple cycle treatment
dc.subjectnon small cell lung cancer
dc.subjectprospective study
dc.subjectblood
dc.subjectcachexia
dc.subjectchemoradiotherapy
dc.subjectlung tumor
dc.subjectmetabolism
dc.subjectmiddle aged
dc.subjectnon small cell lung cancer
dc.subjectpathology
dc.subjectprognosis
dc.subjectvery elderly
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectBody Mass Index
dc.subjectC-Reactive Protein
dc.subjectCachexia
dc.subjectCarcinoma, Non-Small-Cell Lung
dc.subjectChemoradiotherapy
dc.subjectFemale
dc.subjectGhrelin
dc.subjectHumans
dc.subjectLung Neoplasms
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPrognosis
dc.subjectProspective Studies
dc.subjectSerum Albumin, Human
dc.titleEvaluation of the relationship between serum ghrelin levels and cancer cachexia in patients with locally advanced nonsmall-cell lung cancer treated with chemoradiotherapy
dc.typeArticle

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