Evaluation of the relationship between serum ghrelin levels and cancer cachexia in patients with locally advanced nonsmall-cell lung cancer treated with chemoradiotherapy
Küçük Resim Yok
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wolters Kluwer Medknow Publications
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: Ghrelin plays a role in mechanisms related to cancer progression - including cell proliferation, invasion and migration, and resistance to apoptosis in the cell lines from several cancers. We investigated the role of ghrelin levels in cancer cachexia-anorexia in patients with locally advanced nonsmall-cell lung cancer (NSCLC) treated with chemoradiotherapy (CRT). Materials and Methods: This study involved 84 NSCLC patients who had received concomitant CRT. Blood ghrelin levels were compared before and 3 months after CRT. Meanwhile, changes in body weight of the patients were also investigated with changes in ghrelin levels before and after CRT. Results: Ghrelin levels were significantly decreased in line with changes in patients' weights in patients receiving CRT (P < 0.001). Serum albumin levels and inflammatory-nutritional index were significantly decreased after radiotherapy (RT) (3.01 ± 0.40 g/dL, 0.38 ± 0.20) when compared with its baseline levels (3.40 ± 0.55 g/dL,P < 0.001; 0.86 ± 0.71,P < 0.001, respectively). Serum C-reactive protein levels were significantly increased after CRT (7.49 ± 6.53 mg/L) when compared with its baseline levels (9.54 ± 3.80 mg/L,P = 0.038). After RT, ghrelin levels in patients were positively correlated with body mass index (r = 0.830,P < 0.001) and albumin (r = 0.758,P < 0.001). Conclusion: Ghrelin may play a role in the pathogenesis of weight loss in NSCLC patients. Ghrelin seems to be implicated in cancer-related weight loss. Ghrelin, cancer, and RT all together have a role in tumor-related anorexia-cachexia in patients with NSCLC. Results of this study need further evaluation as regards to its potential role as an adjuvant diagnostic or prognostic marker. © 2020 Wolters Kluwer Medknow Publications. All rights reserved.
Açıklama
Anahtar Kelimeler
Cancer cachexia, chemoradiotherapy, ghrelin, locally advanced nonsmall cell lung cancer, albumin, C reactive protein, carboplatin, cisplatin, etoposide, ghrelin, paclitaxel, pemetrexed, vinblastine, C reactive protein, ghrelin, human serum albumin, adult, advanced cancer, aged, albumin blood level, anorexia, Article, blood sampling, body mass, body weight change, cachexia, cancer combination chemotherapy, cancer patient, cancer radiotherapy, chemoradiotherapy, female, human, major clinical study, male, multiple cycle treatment, non small cell lung cancer, prospective study, blood, cachexia, chemoradiotherapy, lung tumor, metabolism, middle aged, non small cell lung cancer, pathology, prognosis, very elderly, Aged, Aged, 80 and over, Body Mass Index, C-Reactive Protein, Cachexia, Carcinoma, Non-Small-Cell Lung, Chemoradiotherapy, Female, Ghrelin, Humans, Lung Neoplasms, Male, Middle Aged, Prognosis, Prospective Studies, Serum Albumin, Human
Kaynak
Journal of Cancer Research and Therapeutics
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
16
Sayı
4
