Refined mapping of twinning-rate quantitative trait loci on bovine chromosome 5 and analysis of insulin-like growth factor-1 as a positional candidate gene

Basit Öğe Kaydı
dc.authorid0000-0001-9671-0784
dc.authorid0000-0001-9633-634X
dc.authorscopusid26424677500
dc.authorscopusid55228145200
dc.authorscopusid9234694200
dc.authorscopusid57204215827
dc.authorscopusid7402865962
dc.authorscopusid7102804280
dc.authorwosidGuntinas-Lichius, Orlando/L-1871-2016
dc.authorwosidCOBANOGLU, Ozden/AAM-4544-2020
dc.contributor.authorKim, E. S.
dc.contributor.authorShi, X.
dc.contributor.authorÇobanoglu, Özden
dc.contributor.authorWeigel, K.
dc.contributor.authorBerger, P. J.
dc.contributor.authorKirkpatrick, B. W.
dc.date.accessioned2022-05-11T14:28:24Z
dc.date.available2022-05-11T14:28:24Z
dc.date.issued2009
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Biyoloji Bölümü
dc.description.abstractTwinning in cattle is a complex trait that is associated with economic loss and health issues such as abortion, dystocia, and reduced calf survival. Twinning-rate QTL have been detected previously on BTA5 in the North American Holstein and Norwegian dairy cattle populations and in a USDA herd selected for high twinning rate. In previous work with the North American Holstein population, the strongest evidence for a QTL was obtained from analysis of an extended, multiple-generation family. Using additional animals, an increased density of SNP marker association tests, and a combined linkage and linkage disequilibrium mapping method, we refined the position of this QTL in the North American Holstein population. Two sets of twinning-rate predicted transmitting abilities estimated during 2 different time periods in the North American dairy cattle population were used to provide validation of results. A total of 106 SNP and 3 microsatellites were used to scan the genomic region between 5 and 80 Mb on BTA5. Combined linkage-linkage disequilibrium analysis identified significant evidence for QTL within the 25- to 35-Mb and 64- to 70-Mb regions of BTA5. The IGF-1 gene (IGF1) was examined as a positional candidate gene and an SNP in intron 2 of IGF1 was significantly associated with twinning rate by using both data sets (P = 0.003 and P = 1.05 x 10(-6)). Replication of this association in other cattle populations will be required to examine the extent of linkage disequilibrium with the underlying quantitative trait nucleotide across breeds.
dc.description.sponsorshipWisconsin Agric. Exp. Stn [4524]; USDA-National Research InitiativeUnited States Department of Agriculture (USDA) [2005-35205-1556]
dc.description.sponsorshipThanks to Chad Bierman (University of Wisconsin, Madison), Corey Geiger (Hoard's Dairyman, Fort Atkinson, WI), Mike Cowan (Genetic Visions, Middleton, WI), Cooperative Dairy DNA Repository (USDA-ARS, Beltsville, MD), Dairy Bull DNA Repository, Genex Cooperative Inc. (Shawno, WI), Alta Genetics (Watertown, WI), Genetic Visions Inc. (Middleton, WI), Semex Alliance (Guelph, Ontario, Canada), ABS Global Inc. (DeForest, WI), Taurus Service Inc. (Mehoopany, PA), Network Genetics (Tunkhannock, PA), Kansas Artificial Breeding Service Unit (Manhattan), and Excelsior Farms (Corona, CA) for provision or assistance in obtaining semen samples used in this study. Thanks to Curt Van Tassell (USDAARS) for assistance in obtaining dairy cattle calving records. This research was supported by Hatch Grant 4524 from the Wisconsin Agric. Exp. Stn. (Madison, WI) and USDA-National Research Initiative grant 2005-35205-1556.
dc.identifier.doi10.2527/jas.2008-1252
dc.identifier.endpage843
dc.identifier.issn0021-8812
dc.identifier.issn1525-3163
dc.identifier.issue3en_US
dc.identifier.pmid18997068
dc.identifier.scopus2-s2.0-62149087454
dc.identifier.scopusqualityQ1
dc.identifier.startpage835
dc.identifier.urihttps://doi.org/10.2527/jas.2008-1252
dc.identifier.urihttps://hdl.handle.net/20.500.11776/6811
dc.identifier.volume87
dc.identifier.wosWOS:000263558600002
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÇobanoglu, Özden
dc.language.isoen
dc.publisherOxford Univ Press Inc
dc.relation.ispartofJournal of Animal Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectbovine
dc.subjectcattle
dc.subjectinsulin-like growth factor-1
dc.subjectovulation
dc.subjecttwin
dc.subjectOvulation Rate
dc.subjectLinkage
dc.subjectCattle
dc.subjectPrediction
dc.subjectIdentity
dc.subjectGenome
dc.subjectMap
dc.titleRefined mapping of twinning-rate quantitative trait loci on bovine chromosome 5 and analysis of insulin-like growth factor-1 as a positional candidate gene
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
6811.pdf
Boyut:
435.02 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Fen Edebiyat Fakültesi Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu