Is it Possible to Treat Osteosarcoma Using Oligonucleotides Confined into Controlled Release Drug Delivery Systems?

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dc.authorid0000-0001-8171-5929
dc.authorid0000-0001-5590-0637
dc.authorid0000-0003-2003-6337
dc.authorid0000-0002-8084-7855
dc.authorscopusid35076796400
dc.authorscopusid56033997900
dc.authorscopusid54894908600
dc.authorscopusid57195723562
dc.authorscopusid35197435300
dc.authorscopusid56258081800
dc.authorscopusid56769801000
dc.authorwosidözbek, hanefi/P-3492-2015
dc.authorwosidAkyuva, Yener/AAV-5706-2020
dc.authorwosidsirin, duygu yasar/AAR-8685-2020
dc.authorwosidKARAARSLAN, Numan/I-6819-2019
dc.authorwosidYILMAZ, Ibrahim/H-6199-2019
dc.authorwosidMahirogullari, Mahir/AAA-4742-2020
dc.authorwosidOzbek, Hanefi/O-3472-2019
dc.contributor.authorTopuk, Savaş
dc.contributor.authorAkyuva, Yener
dc.contributor.authorKaraarslan, Numan
dc.contributor.authorMutlu, Çağrı A.
dc.contributor.authorYılmaz, İbrahim
dc.contributor.authorİşyar, Mehmet
dc.contributor.authorMahiroğulları, Mahir
dc.date.accessioned2022-05-11T14:12:14Z
dc.date.available2022-05-11T14:12:14Z
dc.date.issued2017
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalı
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Biyoloji Bölümü
dc.description.abstractPurpose: The present study aimed to analyze the researches that are at the experimental phase concerning osteosarcoma treatment. The researches included drug delivery systems which allow controlled release and imbue small interfering-/micro-ribonucleic acid. Methods: Without any language preference, we searched US National Library of Medicine National Institutes of Health, Embase, OVID, Cochrane Library database of clinical trials from 1843 to May 25, 2016 and traced all the references of incorporated documents. The data were evaluated using descriptive statistics and the results are shown as frequency (%). Results: We haven't encountered any drug delivery system in which Small interfering ribonucleic acid/ micro ribonucleic acid oligonucleotides were embedded successfully against osteosarcoma. There has been only one research in which hairpin-ribonucleic acid was embedded. Conclusion: It was considered that drug delivery system enabling controlled oligonucleotide release in the treatment period of osteosarcoma was not projected for the clinical use. However, it cannot be neglected that the mentioned experimental studies with regard to osteosarcoma treatment establish the basis of target therapies. The method in question looks promising regarding effective treatment of osteosarcoma in the future.
dc.identifier.doi10.2174/1389201018666170615083455
dc.identifier.endpage522
dc.identifier.issn1389-2010
dc.identifier.issn1873-4316
dc.identifier.issue6en_US
dc.identifier.pmid28641566
dc.identifier.scopus2-s2.0-85029662522
dc.identifier.scopusqualityQ2
dc.identifier.startpage516
dc.identifier.urihttps://doi.org/10.2174/1389201018666170615083455
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5458
dc.identifier.volume18
dc.identifier.wosWOS:000407701900010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKaraarslan, Numan
dc.institutionauthorYaşar Şirin, Duygu
dc.language.isoen
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofCurrent Pharmaceutical Biotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectControlled release
dc.subjectdrug delivery systems
dc.subjectmiRNA
dc.subjectosteosarcoma
dc.subjectsiRNA
dc.subjectpharmacogenomics
dc.subjectSirna Delivery
dc.subjectCells
dc.subjectExpression
dc.subjectGene
dc.subjectProliferation
dc.subjectApoptosis
dc.subjectHydrogels
dc.subjectOncology
dc.titleIs it Possible to Treat Osteosarcoma Using Oligonucleotides Confined into Controlled Release Drug Delivery Systems?
dc.typeArticle

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