Synthesis and biological evaluation of 2,5-di(7-indolyl)-1,3, 4-oxadiazoles, and 2-and 7-indolyl 2-(1,3,4-thiadiazolyl)ketones as antimicrobials

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dc.authorid0000-0002-7347-2223
dc.authorid0000-0001-9245-0356
dc.authorid0000-0001-7739-5686
dc.authorid0000-0002-0951-9621
dc.authorid0000-0001-8137-9988
dc.authorscopusid55326408200
dc.authorscopusid15071243800
dc.authorscopusid36903739400
dc.authorscopusid35516284500
dc.authorscopusid7102951265
dc.authorscopusid7402869005
dc.authorscopusid16833488100
dc.authorwosidk, h/ABA-1339-2020
dc.authorwosidMa, Cong/AAD-2439-2021
dc.authorwosidGriffith, Renate/A-3584-2015
dc.contributor.authorKandemir, Hakan
dc.contributor.authorMa, Cong
dc.contributor.authorKutty, Samuel K.
dc.contributor.authorBlack, David StC.
dc.contributor.authorGriffith, Renate
dc.contributor.authorLewis, Peter J.
dc.contributor.authorKumar, Naresh
dc.date.accessioned2022-05-11T14:29:56Z
dc.date.available2022-05-11T14:29:56Z
dc.date.issued2014
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractA range of novel hydrazine bridged bis-indoles was prepared from readily available indole-7-glyoxyloylchlorides and 7-trichloroacetylindoles and underwent cyclodehydration to produce 2,5-di(7-indolyl)-1,3,4-oxadiazoles and a 2,2'-bi-1,3,4-oxadiazolyl with phosphoryl chloride in ethyl acetate. This efficient protocol was subsequently used for the synthesis of 2-and 7-indolyl 2-(1,3,4-thiadiazolyl) ketones from related indolyl-hydrazine carbothioamides. The synthesised bis-indoles were evaluated for their antimicrobial properties, particularly the inhibition of protein-protein complex formation between RNA polymerase andrfactor and their bactericidal effect on Gram positive Bacillus subtilis and Gram negative Escherichia coli. (C) 2014 Elsevier Ltd. All rights reserved.
dc.description.sponsorshipUniversity of New South Wales; Turkish GovernmentTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK); NHMRCNational Health and Medical Research Council of Australia [APP1008014]
dc.description.sponsorshipWe thank the University of New South Wales and the Turkish Government for their financial support. This work was supported with funding from the NHMRC (APP1008014).
dc.identifier.doi10.1016/j.bmc.2014.01.025
dc.identifier.endpage1679
dc.identifier.issn0968-0896
dc.identifier.issn1464-3391
dc.identifier.issue5en_US
dc.identifier.pmid24525002
dc.identifier.scopus2-s2.0-84896699707
dc.identifier.scopusqualityQ2
dc.identifier.startpage1672
dc.identifier.urihttps://doi.org/10.1016/j.bmc.2014.01.025
dc.identifier.urihttps://hdl.handle.net/20.500.11776/7179
dc.identifier.volume22
dc.identifier.wosWOS:000331729500017
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKandemir, Hakan
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofBioorganic & Medicinal Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBis-indoles
dc.subjectOxadiazoles
dc.subjectThiadiazoles
dc.subjectIndole hydrazides
dc.subjectAntimicrobial
dc.subjectRNA polymerase
dc.subject1,3,4-Oxadiazoles
dc.subjectAgents
dc.subject4,6-Dimethoxyindoles
dc.subjectMild
dc.titleSynthesis and biological evaluation of 2,5-di(7-indolyl)-1,3, 4-oxadiazoles, and 2-and 7-indolyl 2-(1,3,4-thiadiazolyl)ketones as antimicrobials
dc.typeArticle

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