Electrochemical Studies of Olmesartan Medoxomil and its Detection in Pharmaceutical Dosage Forms and Biological Fluids by Cathodic Adsorptive Stripping Voltammetric Method

Basit Öğe Kaydı
dc.authorid0000-0002-5129-5385
dc.authorscopusid25422504200
dc.authorscopusid16039784700
dc.authorscopusid55798756500
dc.authorscopusid7006065730
dc.authorwosidKacar, Ceren/ABB-9363-2020
dc.authorwosidOzturk, funda/G-9435-2014
dc.contributor.authorÖztürk, Funda
dc.contributor.authorKüçükkolbaşı, Semahat
dc.contributor.authorKaçar, Ceren
dc.contributor.authorKılıç, Esma
dc.date.accessioned2022-05-11T14:29:54Z
dc.date.available2022-05-11T14:29:54Z
dc.date.issued2014
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractThe electrochemical properties of olmesartan (OLME) were investigated by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) at hanging mercury drop electrode (HMDE). All studies were based on the irreversible and adsorption-controlled electrochemical reduction signal of OLME at about -1.2 and -1.5 V vs. Ag/AgCl at pH 5.0 in Britton-Robinson (BR) buffer. This adsorptive character of the molecule was used to develop a novel, fully validated, rapid, selective and simple differential pulse cathodic adsorptive stripping voltammeric (DPCAdSV) method for the direct determination of OLME in pharmaceutical dosage form and human urine without time-consuming steps prior to drug assay. Peak current of electrochemical reduction of OLME was found to vary linearly with the concentration in the range from 4.7 x 10(-8) mol L-1 (0.0262 mu g mL(-1)) to 8.3 x 10(-6) mol L-1 (4.636 mu g mL(-1)). In this method, limit of quantification (LOQ) was found to be 5.1 x 10(-7) mol L-1 (0.284 mu g mL(-1)). The method was applied to determine the content of OLME in commercial pharmaceutical preparation and spiked human urine. It was found to be highly accurate and precise, having a relative standard deviation of less than 10% for all applications.
dc.identifier.doi10.5935/0103-5053.20140063
dc.identifier.endpage927
dc.identifier.issn0103-5053
dc.identifier.issn1678-4790
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-84902305052
dc.identifier.scopusqualityQ3
dc.identifier.startpage920
dc.identifier.urihttps://doi.org/10.5935/0103-5053.20140063
dc.identifier.urihttps://hdl.handle.net/20.500.11776/7171
dc.identifier.volume25
dc.identifier.wosWOS:000335817400016
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorÖztürk, Funda
dc.language.isoen
dc.publisherSoc Brasileira Quimica
dc.relation.ispartofJournal of the Brazilian Chemical Society
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectolmesartan
dc.subjectdifferential pulse cathodic adsorptive stripping voltammetry
dc.subjectpharmaceutical dosage form
dc.subjectBehavior
dc.subjectCs-866
dc.subjectPlasma
dc.titleElectrochemical Studies of Olmesartan Medoxomil and its Detection in Pharmaceutical Dosage Forms and Biological Fluids by Cathodic Adsorptive Stripping Voltammetric Method
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
7171.pdf
Boyut:
597.08 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Fen Edebiyat Fakültesi Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu