Evaluation of Calciferol, Cobalamin, and Stromelysin-1 in Patients with Diabetic Peripheral Neuropathy due to Type-2 Diabetes Mellitus

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dc.authorscopusid56715752200
dc.authorscopusid35197435300
dc.authorscopusid57917236500
dc.authorscopusid57200105523
dc.authorscopusid57201362754
dc.authorscopusid7005912992
dc.contributor.authorBilir, Bülent
dc.contributor.authorYılmaz, İbrahim
dc.contributor.authorKaraarslan, Numan
dc.contributor.authorBilir, B.E.
dc.contributor.authorKaplan, Nuray
dc.contributor.authorÖzbek, Hanefi
dc.date.accessioned2023-04-20T08:04:16Z
dc.date.available2023-04-20T08:04:16Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractObjective: To evaluate the relationship between calciferol (vitamin D), cobalamin (vitamin-B12), and Stromelysin-1 (MMP-3) circulating levels in patients with diabetic peripheral neuropathy (DPN), patients with DM type 2 (T2DM) without neuropathy, and healthy control groups. Study Design: Cross-sectional descriptive study. Place and Duration of Study: Department of Internal Medicine, Namik Kemal University of Medicine, Tekirdag, Turkey, between November 2020 and February 2022. Methodology: Healthy, age, and gender matched volunteers who were admitted to the hospital for a check-up with no health problem constituted the control group (n=30). Cases diagnosed with T2DM (n=30) and those with DPN (n=30) comprised the experimental group. Stromelysin-1, calciferol, and cobalamin levels were analysed from blood samples from all groups using enzyme-linked immunosorbent assay (ELISA) with a commercial kit. Tukey's Honest Significant Difference (HSD) test was performed after one-way analysis of variance (ANOVA) for intergroup comparisons. Alpha significance level was accepted as <0.05. Results: There were significant differences in terms of the stromelysin-1, calciferol, and cobalamin levels of both the T2DM and DPN groups compared to healthy volunteers. These differences were statistically significant (p=0.00). There was a very weak negative correlation between stromelysin-1 and calciferol (p=0.972, r=-0.007) and a weak negative correlation between cobalamin and stromelysin-1 (p=0.062, r=-0.345) in DPN patients, without statistical significance. Conclusion: Serum stromelysin-1 expression may be related to DPN progression in diabetic patients and may be a potential marker in DPN. Calciferol and cobalamin levels may also be important in the development of DPN. © 2022 College of Physicians and Surgeons Pakistan. All rights reserved.
dc.description.sponsorshipDPNdiagnosiswithneurologicalhistoryandexaminationiseffec-tive and reliable, rarely supported by neurophysiological, and quantitative sensory tests. So, when diagnosing the cases with DPN, findings on their history of clinical symptoms, neurological examination findings, and sometimes electrophysiological, quantitative sensory, and autonomic function tests were evaluated altogether. In this study, the diagnosis of DPN was made with respect to 2017 American Diabetes Association ?s diabetic neuropathy position statement.9
dc.identifier.doi10.29271/jcpsp.2022.10.1255
dc.identifier.endpage1259
dc.identifier.issn1022-386X
dc.identifier.issue10en_US
dc.identifier.pmid36205267
dc.identifier.scopus2-s2.0-85139322782
dc.identifier.scopusqualityQ3
dc.identifier.startpage1255
dc.identifier.urihttps://doi.org/10.29271/jcpsp.2022.10.1255
dc.identifier.urihttps://hdl.handle.net/20.500.11776/11063
dc.identifier.volume32
dc.identifier.wosWOS:000886033700005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBilir, Bülent
dc.language.isoen
dc.publisherCollege of Physicians and Surgeons Pakistan
dc.relation.ispartofJournal of the College of Physicians and Surgeons Pakistan
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCalciferol
dc.subjectcobalamin
dc.subjectDiabetic peripheral neuropathy
dc.subjectStromelysin-1
dc.subjectcobalamin
dc.subjectergocalciferol
dc.subjectstromelysin
dc.subjectcyanocobalamin
dc.subjectergocalciferol
dc.subjectnicotinamide adenine dinucleotide
dc.subjectstromelysin
dc.subjectvitamin
dc.subjectvitamin D
dc.subjectadult
dc.subjectArticle
dc.subjectblood sampling
dc.subjectclinical evaluation
dc.subjectcontrolled study
dc.subjectcross-sectional study
dc.subjectdiabetic neuropathy
dc.subjectdisease course
dc.subjectfemale
dc.subjectgroups by age
dc.subjecthospital admission
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmedical examination
dc.subjectmiddle aged
dc.subjectnon insulin dependent diabetes mellitus
dc.subjectpathogenesis
dc.subjectprotein blood level
dc.subjectprotein expression
dc.subjectsex ratio
dc.subjectvitamin blood level
dc.subjectdiabetic neuropathy
dc.subjectnon insulin dependent diabetes mellitus
dc.subjectCross-Sectional Studies
dc.subjectDiabetes Mellitus, Type 2
dc.subjectDiabetic Neuropathies
dc.subjectErgocalciferols
dc.subjectHumans
dc.subjectMatrix Metalloproteinase 3
dc.subjectNAD
dc.subjectVitamin B 12
dc.subjectVitamin D
dc.subjectVitamins
dc.titleEvaluation of Calciferol, Cobalamin, and Stromelysin-1 in Patients with Diabetic Peripheral Neuropathy due to Type-2 Diabetes Mellitus
dc.typeArticle

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