Evaluation of Calciferol, Cobalamin, and Stromelysin-1 in Patients with Diabetic Peripheral Neuropathy due to Type-2 Diabetes Mellitus
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Dosyalar
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
College of Physicians and Surgeons Pakistan
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: To evaluate the relationship between calciferol (vitamin D), cobalamin (vitamin-B12), and Stromelysin-1 (MMP-3) circulating levels in patients with diabetic peripheral neuropathy (DPN), patients with DM type 2 (T2DM) without neuropathy, and healthy control groups. Study Design: Cross-sectional descriptive study. Place and Duration of Study: Department of Internal Medicine, Namik Kemal University of Medicine, Tekirdag, Turkey, between November 2020 and February 2022. Methodology: Healthy, age, and gender matched volunteers who were admitted to the hospital for a check-up with no health problem constituted the control group (n=30). Cases diagnosed with T2DM (n=30) and those with DPN (n=30) comprised the experimental group. Stromelysin-1, calciferol, and cobalamin levels were analysed from blood samples from all groups using enzyme-linked immunosorbent assay (ELISA) with a commercial kit. Tukey's Honest Significant Difference (HSD) test was performed after one-way analysis of variance (ANOVA) for intergroup comparisons. Alpha significance level was accepted as <0.05. Results: There were significant differences in terms of the stromelysin-1, calciferol, and cobalamin levels of both the T2DM and DPN groups compared to healthy volunteers. These differences were statistically significant (p=0.00). There was a very weak negative correlation between stromelysin-1 and calciferol (p=0.972, r=-0.007) and a weak negative correlation between cobalamin and stromelysin-1 (p=0.062, r=-0.345) in DPN patients, without statistical significance. Conclusion: Serum stromelysin-1 expression may be related to DPN progression in diabetic patients and may be a potential marker in DPN. Calciferol and cobalamin levels may also be important in the development of DPN. © 2022 College of Physicians and Surgeons Pakistan. All rights reserved.
Açıklama
Anahtar Kelimeler
Calciferol, cobalamin, Diabetic peripheral neuropathy, Stromelysin-1, cobalamin, ergocalciferol, stromelysin, cyanocobalamin, ergocalciferol, nicotinamide adenine dinucleotide, stromelysin, vitamin, vitamin D, adult, Article, blood sampling, clinical evaluation, controlled study, cross-sectional study, diabetic neuropathy, disease course, female, groups by age, hospital admission, human, major clinical study, male, medical examination, middle aged, non insulin dependent diabetes mellitus, pathogenesis, protein blood level, protein expression, sex ratio, vitamin blood level, diabetic neuropathy, non insulin dependent diabetes mellitus, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Diabetic Neuropathies, Ergocalciferols, Humans, Matrix Metalloproteinase 3, NAD, Vitamin B 12, Vitamin D, Vitamins
Kaynak
Journal of the College of Physicians and Surgeons Pakistan
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
32
Sayı
10
