Effects of quercetin and fish n-3 fatty acids on testicular injury induced by ethanol in rats

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dc.authorid0000-0001-6404-4510
dc.authorid0000-0002-6683-5495
dc.authorid0000-0001-9774-8151
dc.authorscopusid26434076100
dc.authorscopusid6602371887
dc.authorscopusid24470924300
dc.authorscopusid23049681600
dc.authorscopusid6603136404
dc.authorscopusid23053121600
dc.authorscopusid6603048599
dc.authorwosidyagmurca, murat/A-1851-2018
dc.authorwosidYAĞMURCA, Murat/AAH-4496-2019
dc.authorwosidUcok, Kagan/J-9685-2015
dc.contributor.authorUygur, Ramazan
dc.contributor.authorYağmurca, Murat
dc.contributor.authorAlkoç, Ozan Alper
dc.contributor.authorGenç, Abdurrahman
dc.contributor.authorSongur, Ahmet
dc.contributor.authorÜçok, Kağan
dc.contributor.authorÖzen, Oğuz Aslan
dc.date.accessioned2022-05-11T14:41:18Z
dc.date.available2022-05-11T14:41:18Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Anatomi Ana Bilim Dalı
dc.description.abstractThe aim of this study was to investigate the effects of quercetin and fish n-3 fatty acids on the changes in testis induced by ethanol. Forty-five rats divided into five groups, control, ethanol, ethanol+quercetin, ethanol+fish n-3 fatty acids and ethanol+quercetin+fish n-3 fatty acids. Atthe end of 8weeks, all the rats were sacrificed. Degenerative changes in histopathological analyses, the decreased body weight gain and seminiferous tubule diameters in ethanol group have been observed. TUNEL assay also showed an increase in apoptotic cell number. The activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), xanthine oxidase (XO) and testosterone levels were decreased as well as the levels of malondialdehyde (MDA) and nitric oxide (NO) were increased in ethanol group. Histopathological changes caused by ethanol have been improved by quercetin and fish n-3 fatty acids. It was also found that protection was provided by increasing SOD, CAT and GSH-Px activities in groups administered quercetin, fish n-3 fatty acids and quercetin+fish n-3 fatty acids, and by decreasing the levels of MDA and NO in groups administered both quercetin and fish n-3 fatty acids together. These results suggest that quercetin and fish n-3 fatty acids are beneficial agents to reduce testicular injury induced by ethanol except for testosterone levels.
dc.description.sponsorshipAfyon Kocatepe University Scientific Research Projects Coordination UnitAfyon Kocatepe University [10.TIP.02]
dc.description.sponsorshipThis study was supported by Afyon Kocatepe University Scientific Research Projects Coordination Unit (Project Number: 10.TIP.02).
dc.identifier.doi10.1111/and.12085
dc.identifier.endpage369
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue4en_US
dc.identifier.pmid23488863
dc.identifier.scopus2-s2.0-84897064546
dc.identifier.scopusqualityQ2
dc.identifier.startpage356
dc.identifier.urihttps://doi.org/10.1111/and.12085
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9137
dc.identifier.volume46
dc.identifier.wosWOS:000333673900004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorUygur, Ramazan
dc.institutionauthorÖzen, Oğuz Aslan
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofAndrologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectEthanol
dc.subjectfish n-3 fatty acids
dc.subjectquercetin
dc.subjectrat
dc.subjecttestis
dc.subjectXanthine-Oxidase Activity
dc.subjectInduced Oxidative Stress
dc.subjectLipid-Peroxidation
dc.subjectLeydig-Cells
dc.subjectSuperoxide-Dismutase
dc.subjectTestosterone Levels
dc.subjectReperfusion Injury
dc.subjectPrefrontal Cortex
dc.subjectPhenethyl Ester
dc.subjectGerm-Cells
dc.titleEffects of quercetin and fish n-3 fatty acids on testicular injury induced by ethanol in rats
dc.typeArticle

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