Effects of quercetin and fish n-3 fatty acids on testicular injury induced by ethanol in rats
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Dosyalar
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The aim of this study was to investigate the effects of quercetin and fish n-3 fatty acids on the changes in testis induced by ethanol. Forty-five rats divided into five groups, control, ethanol, ethanol+quercetin, ethanol+fish n-3 fatty acids and ethanol+quercetin+fish n-3 fatty acids. Atthe end of 8weeks, all the rats were sacrificed. Degenerative changes in histopathological analyses, the decreased body weight gain and seminiferous tubule diameters in ethanol group have been observed. TUNEL assay also showed an increase in apoptotic cell number. The activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), xanthine oxidase (XO) and testosterone levels were decreased as well as the levels of malondialdehyde (MDA) and nitric oxide (NO) were increased in ethanol group. Histopathological changes caused by ethanol have been improved by quercetin and fish n-3 fatty acids. It was also found that protection was provided by increasing SOD, CAT and GSH-Px activities in groups administered quercetin, fish n-3 fatty acids and quercetin+fish n-3 fatty acids, and by decreasing the levels of MDA and NO in groups administered both quercetin and fish n-3 fatty acids together. These results suggest that quercetin and fish n-3 fatty acids are beneficial agents to reduce testicular injury induced by ethanol except for testosterone levels.
Açıklama
Anahtar Kelimeler
Ethanol, fish n-3 fatty acids, quercetin, rat, testis, Xanthine-Oxidase Activity, Induced Oxidative Stress, Lipid-Peroxidation, Leydig-Cells, Superoxide-Dismutase, Testosterone Levels, Reperfusion Injury, Prefrontal Cortex, Phenethyl Ester, Germ-Cells
Kaynak
Andrologia
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
46
Sayı
4
