Muscle structure and gene expression in pectoralis major muscle in response to deep pectoral myopathy induction in fast- and slow-growing commercial broilers

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dc.authorid0000-0003-4194-0536
dc.authorid0000-0001-9542-5244
dc.authorid0000-0002-9637-882X
dc.authorid0000-0003-2982-6562
dc.authorid0000-0003-2982-6562
dc.authorid0000-0001-9828-2402
dc.authorid0000-0002-1329-3143
dc.authorscopusid56207790200
dc.authorscopusid16639623900
dc.authorscopusid14632863800
dc.authorscopusid6508345605
dc.authorscopusid7102661493
dc.authorscopusid35220657000
dc.authorscopusid57200696504
dc.authorwosidYALCIN, Servet/F-4519-2011
dc.authorwosidSahin, Kazim/D-5625-2009
dc.authorwosidİzzetoğlu, Gamze Turgay/A-7543-2018
dc.authorwosidOzkan, Sezen/F-2633-2011
dc.authorwosidIşık, Raziye/V-4030-2017
dc.authorwosidISIK, RAZIYE/O-2454-2019
dc.authorwosidTuzcu, Mehmet/H-2953-2018
dc.contributor.authorYalçın, S.
dc.contributor.authorŞahin, K.
dc.contributor.authorTuzcu, M.
dc.contributor.authorBilgen, G.
dc.contributor.authorÖzkan, S.
dc.contributor.authorİzzetoğlu, G. T.
dc.contributor.authorIşık, Raziye
dc.date.accessioned2022-05-11T14:45:29Z
dc.date.available2022-05-11T14:45:29Z
dc.date.issued2019
dc.departmentFakülteler, Ziraat Fakültesi, Tarımsal Biyoteknoloji Bölümü
dc.description.abstract1. The objective of this study was to determine muscle structure and gene expression in pectoralis major (p. major) muscle of broilers in response to deep pectoral myopathy (DPM) induction.2. A total of 160 chickens from slow- and fast-growing broilers were raised under same conditions. Half of the broilers from each strain were encouraged to wing flap when they reached 2800g body weight. Pectoralis minor (p. minor) muscle of the broilers was inspected for the occurrence of DPM and p. major samples were collected from broilers with or without DPM. The muscle fibre area and number, capillary number and the signalling pathways of vascular development (vascular endothelial growth factor A, VEGFA) and muscle contraction regulation (actin alpha 1, ACTA1; myosin light chain kinase 2, MYLK2 and ATPase Ca+2 transporting gene 1, ATP2A1) were studied in p. major muscle.3. DPM induction increased fibre area of p. major muscle with a greater rate in the slow-growing strain compared with fast-growing line. Although the capillary number was higher in slow-growing compared with fast-growing broilers, in the case of DPM induction, the number of capillaries was similar between strains.4. Expression of VEGFA, MYLK2 and ATP2A1 was greater in slow- than in fast-growing broilers. DPM induction increased expression of ACTA1, VEGFA and ATP2A1 in p. major muscle of broilers from both strains; however, MYLK2 expression was downregulated.5. Changes in capillary density and expression of VEGFA found in the p. major muscle of broilers with DPM suggest increased blood flow to increase oxygen availability. The upregulation of ATP2A1 by DPM induction could be attributable to alterations in calcium ion transportation from the cytoplasm into the sarcoplasmic reticulum.6. The results are evidence of changes in muscle structure and gene expression pathways in p. major muscle of broilers with DPM.
dc.description.sponsorshipScientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [115O434]
dc.description.sponsorshipThis work was supported by The Scientific and Technological Research Council of Turkey [115O434].
dc.identifier.doi10.1080/00071668.2018.1430351
dc.identifier.endpage201
dc.identifier.issn0007-1668
dc.identifier.issn1466-1799
dc.identifier.issue3en_US
dc.identifier.pmid29355388
dc.identifier.scopus2-s2.0-85042231716
dc.identifier.scopusqualityQ2
dc.identifier.startpage195
dc.identifier.urihttps://doi.org/10.1080/00071668.2018.1430351
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10058
dc.identifier.volume60
dc.identifier.wosWOS:000473525000002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorIşık, Raziye
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofBritish Poultry Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBroiler
dc.subjectdeep pectoral myopathy
dc.subjectfibre
dc.subjectgene expression
dc.subjectmuscle
dc.subjectBreast Meat Quality
dc.subjectSkeletal-Muscle
dc.subjectGrowth
dc.subjectChickens
dc.subjectCapillary
dc.subjectSelection
dc.subjectYield
dc.subjectPhosphorylation
dc.subjectRegeneration
dc.subjectCalcium
dc.titleMuscle structure and gene expression in pectoralis major muscle in response to deep pectoral myopathy induction in fast- and slow-growing commercial broilers
dc.typeArticle

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