Acute Stroke Management in Türkiye: Intravenous Tissue Plasminogen Activator and Thrombectomy NöroTek: Türkiye Neurology Single Day Study

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dc.authoridarslan, yildiz/0000-0001-8818-9423
dc.authoridBekdik, Pinar/0000-0002-4644-6572
dc.authoridGULER, AYSE/0000-0003-4465-3743
dc.authoridIlgezdi, Irem/0000-0001-5376-9700
dc.authoridKayim Yildiz, Ozlem/0000-0002-0382-9135
dc.authoridOzdemir, Zeynep/0000-0002-6403-4133
dc.contributor.authorTopcuoglu, Mehmet Akif
dc.contributor.authorOzdemir, Atilla Ozcan
dc.contributor.authorArsava, Ethem Murat
dc.contributor.authorGunes, Aygul
dc.contributor.authorAykac, Özlem
dc.contributor.authorGencer, Elif Sarionder
dc.contributor.authorCabalar, Murat
dc.date.accessioned2024-10-29T17:59:39Z
dc.date.available2024-10-29T17:59:39Z
dc.date.issued2023
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractObjective: To reveal the profile and practice in patients with acute stroke who received intravenous tissue plasminogen activator (IV tPA) and/or neurointerventional therapy in Turkiye. Materials and Methods: On World Stroke Awareness Day, May 10, 2018, 1,790 patients hospitalized in 87 neurology units spread over 30 health regions were evaluated retrospectively and prospectively. Results: Intravenous tPA was administered to 12% of 859 cases of acute ischemic stroke in 45 units participating in the study. In the same period, 8.3% of the cases received neurointerventional treatment. The rate of good prognosis [modified Rankin score (mRS) 0-2] at discharge was 46% in 83 patients who received only IV tPA [age: 67 +/- 12 years; National Institutes of Health Stroke Scale (NIHSS): 12 +/- 6; hospital stay, 24 +/- 29 days]; 35% in 51 patients who underwent thrombectomy (MT) alone (age: 64 +/- 13 years; NIHSS: 14.1 +/- 6.5; length of hospital stay, 33 +/- 31 days), 19% in those who received combined treatment (age: 66 +/- 14 years; NIHSS: 15.6 +/- 5.4; length of hospital stay, 26 +/- 35 days), and 56% of 695 patients who did not receive treatment for revascularization (age: 70 +/- 13 years; NIHSS: 7.6 +/- 7.2; length of hospital stay, 21 +/- 28 days). The symptom-to-door time was 87 +/- 53 minutes in the IV treatment group and 200 +/- 26 minutes in the neurointerventional group. The average door-to-needle time was 66 +/- 49 minutes in the IV tPA group. In the neurothrombectomy group, the door-to-groin time was 103 +/- 90 minutes, and the TICI 2b-3 rate was 70.3%. In 103 patients who received IV tPA, the discharge mRS 0-2 was 41%, while the rate of mRS 0-1 was 28%. In 71 patients who underwent neurothrombectomy, the mRS 0-2 was 31% and mRS 0-1 was 18%. The door-to-groin time was approximately 30 minutes longer if IV tPA was received (125 +/- 107 and 95 +/- 83 minutes, respectively). Symptomatic bleeding rates were 4.8% in IV recipients, 17.6% among those who received only MT, and 15% in combined therapy. Globally, the hemorrhage rate was 6.8% in patients receiving IV tPA and 16.9% in MT. Conclusion: IV thrombolytic and neurointerventional treatment applications in acute ischemic stroke in Turkiye can provide the anticipated results. Heterogeneity has begun to be reduced in our country with the dissemination of the system indicated by the Directive on Health Services to be Provided to Patients with Acute Stroke.
dc.identifier.doi10.4274/tnd.2023.70292
dc.identifier.endpage255
dc.identifier.issn1301-062X
dc.identifier.issn1309-2545
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85180871690
dc.identifier.scopusqualityQ4
dc.identifier.startpage249
dc.identifier.trdizinid#BAŞV!
dc.identifier.urihttps://doi.org/10.4274/tnd.2023.70292
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1254393
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14801
dc.identifier.volume29
dc.identifier.wosWOS:001137624800014
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherGalenos Publ House
dc.relation.ispartofTurkish Journal of Neurology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAcute stroke
dc.subjectthrombolytic therapy
dc.subjectthrombectomy
dc.subjectprognosis
dc.subjecttreatment window
dc.subjectmetric
dc.titleAcute Stroke Management in Türkiye: Intravenous Tissue Plasminogen Activator and Thrombectomy NöroTek: Türkiye Neurology Single Day Study
dc.title.alternativeTürkiye’de Akut İnme Yönetimi: IV tPA ve Trombektomi NöroTek: Türkiye Nöroloji Tek Gün Çalışması
dc.typeArticle

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