Glutathione-responsive multifunctionalizable hydrogels via amine-epoxy "click" chemistry

Yükleniyor...
Küçük Resim

Tarih

2020

Yazarlar

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Elsevier Ltd

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

A novel glutathione-responsive hydrogel was synthesized through catalyst-free epoxy-amine ‘click’ chemistry using PEG-diamine and a redox-responsive diepoxy crosslinker. The chain length of PEG-diamine component was varied to modulate the physical characteristics of thus obtained hydrogels. Hydrogels exhibited degradation upon treatment with glutathione, as evident through visually apparanet gel disolution and rheological measurements. The unreacted epoxy and newly formed hydroxyl groups post-gelation were used as reactive handles to functionalize the hydrogels, as demonstrated through attachment of different fluorescent probes. Finally, it was also established that these hydrogels provide an efficient platform for ligand-directed biomolecular immobilization through anchoring of a fluorescently labelled protein onto the hydrogels. © 2019 Elsevier Ltd

Açıklama

Anahtar Kelimeler

Epoxy-amine click, Glutathione, Hydrogel, Redox-responsive, Amines, Gelation, Peptides, Biomolecular immobilization, Epoxy amine, Fluorescent probes, Glutathiones, Physical characteristics, Redox-responsive, Responsive hydrogels, Rheological measurements, Hydrogels

Kaynak

European Polymer Journal

WoS Q Değeri

Scopus Q Değeri

Q1

Cilt

123

Sayı

Künye