THE DETERMINANTS IN THE MANAGEMENT OF PREGNANCIES COMPLICATED WITH IMMUNE THROMBOCYTOPENIA

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dc.contributor.authorIsguder, Cigdem Kunt
dc.contributor.authorSivrikoz, Tugba Sarac
dc.contributor.authorAkin, Mehtap
dc.contributor.authorAslan, Torehan
dc.contributor.authorUygur, Lutfiye Selcuk
dc.contributor.authorInce, Sule Birol
dc.contributor.authorKalelioglu, Ibrahim
dc.date.accessioned2024-10-29T17:59:04Z
dc.date.available2024-10-29T17:59:04Z
dc.date.issued2023
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractObjective: This study aims to determine the hematologic and obstetric factors that would affect the management of immune thrombocytopenia (ITP) during pregnancy.Material and Method: This is a retrospective review of 54 pregnancies that were complicated by ITP at a single tertiary center. All of the patients were followed-up and delivered at the same center. Subgroup analysis for obstetric outcomes was made accord-ing to the platelet counts at the time of delivery (<50x10(3)/mm(3) or 250x10(3)/mm(3)), the time of diagnosis (before or during pregnancy) and neonatal platelet counts (<= 100x10(3)/mm(3) or >100x103/mm3).Result: Transfusion of blood products, steroid administration per se, or in combination with intravenous immunoglobulins (IVIG), were significantly more often administered in those with platelet counts <50x10(3)/mm(3) at the time of delivery (p=0.020, p=0.020, and p=0.004, respectively). The patients who were first diagnosed with ITP during pregnancy had higher rates of transfusion of blood products (p=0.041), higher rates of vaginal deliveries (p=0.048), and lower rates of preterm delivery (p=0.044) when compared to the patients who had ITP diagnosed before the on- set of pregnancy. Gestational age at birth (p=0.020), birth weight (p=0.002) and neonatal platelet count (p=0.002) were significantly higher in those who were diagnosed during the pregnancy. History of maternal splenectomy, intensive care unit admission, IVIG administration, and blood transfusion were significantly more frequent in neonates with platelet counts <= 100x10(3)/mm(3) (p=0.028, p=0.001, p=0.001, and p=0.025, respectively).Conclusion: The women diagnosed with ITP before the pregnancy and those who were diagnosed during the pregnancy had comparable rates of postpartum bleeding. However, there was a tendency towards overtreatment of the women who developed ITP during pregnancy.
dc.identifier.doi10.26650/IUITFD.1257385
dc.identifier.endpage301
dc.identifier.issn1305-6441
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85181806721
dc.identifier.scopusqualityQ4
dc.identifier.startpage295
dc.identifier.trdizinid1244068
dc.identifier.urihttps://doi.org/10.26650/IUITFD.1257385
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1244068
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14612
dc.identifier.volume86
dc.identifier.wosWOS:001085176100001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherIstanbul Univ, Fac Medicine, Publ Off
dc.relation.ispartofJournal of Istanbul Faculty of Medicine-Istanbul Tip Fakultesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectImmune thrombocytopenia
dc.subjectpregnancy
dc.subjectbleeding
dc.titleTHE DETERMINANTS IN THE MANAGEMENT OF PREGNANCIES COMPLICATED WITH IMMUNE THROMBOCYTOPENIA
dc.title.alternativeTHE DETERMINANTS IN THE MANAGEMENT OF PREGNANCIES COMPLICATED WITH IMMUNE THROMBOCYTOPENIA
dc.typeArticle

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