Decrease of left ventricular ejection fraction in severe illness patients due to COVID-19 may improve as the disease resolves

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dc.authorscopusid35195470300
dc.authorscopusid55765181800
dc.authorscopusid57196589837
dc.contributor.authorDemirkiran, Aykut
dc.contributor.authorOnar, L. Ç.
dc.contributor.authorDoğan, Mustafa
dc.date.accessioned2022-05-11T14:05:00Z
dc.date.available2022-05-11T14:05:00Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground/aim: Increase in publications supporting myocardial involvement in the COVID-19 disease has led to need to gain insight into the the global burden of heart failure after pandemic. We examined the course of myocardial systolic function in patients without elevated troponin levels. Materials and methods: We performed a prospective study. Patients with high troponin levels were excluded from the study in order to definitively exclude complications known to cause permanent left ventricular systolic dysfunction, such as acute coronary syndromes. Two echocardiographic examinations were performed. The first evaluation was performed within the days of hospitalization, if possible, on the day when dyspnea is severe. The second evaluation was performed during the outpatient clinic controls one month after the patient was recovered. Left ventricular ejection fraction (LVEF) was measured using the biplane method of disks (modified Simpson’s rule). Results: In the first evaluation, LVEF was found to be significantly lower in the severe illness group than mild/moderate illness group (50 ± 6% and 59 ± 6%; p = 0.03). LVEF decrease (<50%) was found in fifteen patients (43 ± 4%) and detected as global hypokinesia but not segmental. All of these patients were in the severe illness group. In the second evaluation, LVEFs of the fifteen patients with decreased LVEF in the first evaluation were improved and detected in normal limits (first evaluation = 43 ± 4% and second evaluation = 55 ± 2%, p = 0.01). Conclusion: Considering patients without elevated troponin levels during COVID-19 infection, no permanent systolic dysfunction was detected after first month of recovery. We found that transient myocardial dysfunction may develop in the severe illness group with normal troponin levels, LVEF may decrease in the acute phase and improve with the recovery period. © TÜBİTAK.
dc.description.sponsorshipWe appreciate Tekirda? Provincial Health Director Ali Cengiz Kalkan for providing support and thank Dr. Hasan De?irmenci and Dr. Ulugbin Hayri for their contribution in the examination of the patients.Funding This study was funded by Aykut Demirk?ran, Hasan De?irmenci, and Ulug Bey Hayri. The study protocol received institutional review board approval. All participants provided informed consent.
dc.identifier.doi10.3906/sag-2101-198
dc.identifier.endpage2869
dc.identifier.issn1300-0144
dc.identifier.issue6en_US
dc.identifier.pmid34493031
dc.identifier.scopus2-s2.0-85122903562
dc.identifier.scopusqualityQ3
dc.identifier.startpage2861
dc.identifier.urihttps://doi.org/10.3906/sag-2101-198
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4866
dc.identifier.volume51
dc.identifier.wosWOS:000731456300007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDoğan, Mustafa
dc.language.isoen
dc.publisherTurkiye Klinikleri
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCOVID-19
dc.subjectLeft ventricular ejection fraction
dc.subjectMyocardial dysfunction
dc.subjecttroponin
dc.subjectadult
dc.subjectblood
dc.subjectcomplication
dc.subjectdiagnosis
dc.subjectdiagnostic imaging
dc.subjectechocardiography
dc.subjectfemale
dc.subjectgenetics
dc.subjectheart left ventricle function
dc.subjectheart stroke volume
dc.subjecthuman
dc.subjectisolation and purification
dc.subjectmale
dc.subjectmiddle aged
dc.subjectphysiology
dc.subjectprospective study
dc.subjectreverse transcription polymerase chain reaction
dc.subjectseverity of illness index
dc.subjectAdult
dc.subjectCOVID-19
dc.subjectEchocardiography
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectProspective Studies
dc.subjectReverse Transcriptase Polymerase Chain Reaction
dc.subjectSARS-CoV-2
dc.subjectSeverity of Illness Index
dc.subjectStroke Volume
dc.subjectTroponin
dc.subjectVentricular Dysfunction, Left
dc.subjectVentricular Function, Left
dc.titleDecrease of left ventricular ejection fraction in severe illness patients due to COVID-19 may improve as the disease resolves
dc.typeArticle

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