Synthesis, characterization and cytotoxic properties of bismuth(III) chloride complexes with heterocyclic thioamides

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dc.authorid0000-0001-9556-6266
dc.authorid0000-0003-3164-0038
dc.authorid0000-0001-6727-2711
dc.authorid0000-0002-4804-3822
dc.authorid0000-0003-1786-326X
dc.authorscopusid57192317122
dc.authorscopusid36785856200
dc.authorscopusid46860923200
dc.authorscopusid57196276440
dc.authorscopusid15124078400
dc.authorscopusid14525091600
dc.authorscopusid56884173600
dc.authorwosidHadjikakou, Sotiris K./I-2909-2019
dc.authorwosidOzturk, Ibrahim Ismet/K-1352-2013
dc.contributor.authorYarar, S.
dc.contributor.authorÖztürk, İbrahim İsmet
dc.contributor.authorBanti, Christina N.
dc.contributor.authorPanagiotou, Nikos
dc.contributor.authorPapatriantafyllopoulou, C.
dc.contributor.authorManoli, Maria
dc.contributor.authorHadjikakou, Sotiris K.
dc.date.accessioned2022-05-11T14:31:00Z
dc.date.available2022-05-11T14:31:00Z
dc.date.issued2018
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractBismuth(III) complexes of the formulae [BiCl3(MBZT)(2)] center dot H2O} (1), {[BiCl2(mu(2)-Cl)(MMI)(2)](2)center dot(CH3)(2)CO} (2), {[BiCl3(mu(2)-S-PYT)(PYT)](2)} (3) {([BiCl2(MBZIM)(4)](+))center dot 2(Cl-) center dot(H3O+)center dot 2H(2)O} (4) and [BiCl3(tHPMT)(3)] (5) (where MBZT: 2-mercaptobenzothiazole, MMI: 2-mercapto-1-methylimidazole, PYT: 2-mercaptopyridine, MBZIM: 2-mercaptobenzimidazole, tHPMT: 2-mercapto-3,4,5,6-tetrahydro-pyrimidine) are reported. The compounds were characterized by spectroscopic techniques including FT-IR, FT-Raman, UV-Vis, H-1-, C-13-NMR spectroscopies, TG-DTA, e. a, molar conductivity and by single-crystal X-ray diffraction analysis. While 1, 4 and 5 are mononuclear compounds, 2 and 3 are dinuclear complexes in which the two Bi3+ ions are bridged through Cl- and SR groups respectively. Interestingly, 3 is the first example of dinuclear Bi3+ complex containing two Bi-(mu-SR)-Bi bridges between the two metal centers formed by covalent bonds. Compounds 1-5 were evaluated for their in vitro cytotoxic activity against human adenocarcinoma cervix (HeLa) and breast (MCF-7) cells. The toxicity of 1-5 was evaluated on normal human fetal lung fibroblast cells (MRC-5). The influence of 1-5, on the catalytic peroxidation of the linoleic acid by the enzyme lipoxygenase (LOX) was determined experimentally. (C) 2017 Elsevier B.V. All rights reserved.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [114Z457]; Oncology Department of Novartis Hellas S.A.C.I [81939]
dc.description.sponsorshipThis research was carried out in partial fulfillment of the requirements for the master thesis of S.Y. under the supervision of I.I.O. I.I.O. and S.Y. acknowledge the financial support from The Scientific and Technological Research Council of Turkey (TUBITAK, Project No. 114Z457). The Unit of Bioactivity Testing of Xenobiotics, of the University of Ioannina-Greece, is also acknowledged for providing access to the facilities. CNB and SKH acknowledge the Oncology Department of Novartis Hellas S.A.C.I. for the financial support to CNB (project number: 81939).
dc.identifier.doi10.1016/j.ica.2017.10.026
dc.identifier.endpage33
dc.identifier.issn0020-1693
dc.identifier.issn1873-3255
dc.identifier.scopus2-s2.0-85032497403
dc.identifier.scopusqualityQ2
dc.identifier.startpage23
dc.identifier.urihttps://doi.org/10.1016/j.ica.2017.10.026
dc.identifier.urihttps://hdl.handle.net/20.500.11776/7272
dc.identifier.volume471
dc.identifier.wosWOS:000419826000004
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorYarar, S.
dc.institutionauthorÖztürk, İbrahim İsmet
dc.language.isoen
dc.publisherElsevier Science Sa
dc.relation.ispartofInorganica Chimica Acta
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBiological Inorganic Chemistry
dc.subjectDrug design
dc.subjectBismuth(III) chloride
dc.subjectCell studies
dc.subjectLipoxygenase inhibition
dc.subjectAntimony(Iii) Halide-Complexes
dc.subjectBiological Evaluation
dc.subjectCrystal-Structure
dc.subjectStructural-Characterization
dc.subjectMedicinal Chemistry
dc.subjectIn-Vitro
dc.subjectLigands
dc.subject6-Mercaptopurine
dc.subjectThiones
dc.subjectOrganotin(Iv)
dc.titleSynthesis, characterization and cytotoxic properties of bismuth(III) chloride complexes with heterocyclic thioamides
dc.typeArticle

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