Prophylactic feeding with immune-enhanced diet ameliorates chemoradiation-induced gastrointestinal injury in rats

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dc.authorid0000-0003-1320-9105
dc.authorid0000-0003-0791-0165
dc.authorid0000-0002-3950-8616
dc.authorid0000-0003-0791-0165
dc.authorid0000-0002-6044-1372
dc.authorscopusid6506384414
dc.authorscopusid6602177993
dc.authorscopusid8581432900
dc.authorscopusid6507358355
dc.authorscopusid56632247800
dc.authorscopusid7006979286
dc.authorscopusid6603868744
dc.authorwosidYegen, Berrak/ABA-3274-2020
dc.authorwosidAtasoy, Beste/AAG-9232-2021
dc.authorwosidYeğen, Berrak/O-6652-2017
dc.authorwosidAtasoy, Beste/L-5144-2015
dc.authorwosidAbacioglu, Ufuk/AAM-1813-2020
dc.authorwosidYegen, Berrak C./ABA-1986-2020
dc.contributor.authorAtasoy, Beste M.
dc.contributor.authorDeniz, Mustafa
dc.contributor.authorDane, Faysal
dc.contributor.authorÖzen, Zeynep
dc.contributor.authorTuran, Pınar
dc.contributor.authorErcan, Feriha
dc.contributor.authorYegen, Berrak C.
dc.contributor.authorAral, Cenk
dc.date.accessioned2022-05-11T14:28:25Z
dc.date.available2022-05-11T14:28:25Z
dc.date.issued2010
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Biyoloji Bölümü
dc.description.abstractMaterials and methods: Forty-eight Sprague-Dawley rats were divided into control (C, n = 6), irradiation (IR, n = 14), fluoropyrimidine (5-FU, n = 14)-treated, IR + 5-FU (n = 14)-treated groups. Half of each irradiated and/or 5-FU-treated groups were previously fed with IED containing arginine, omega-3-fatty acids and RNA fragments, while the other half were fed a standard rat diet (SD) for eight days before the induction of IR or injection of 5-FU. In IR groups, whole abdominal irradiation (11 Gy) was performed with 6 MV photons. In the 5-FU groups, fluoropyrimidine (100 mg/kg) was administered intraperitoneally 30 min prior to irradiation. All animals were sacrificed on the 4th day of IR or 5-FU injection. Results: Bacterial colony counts in the ceca and mesenteric lymph nodes of IED-fed rats, which have received either 5-FU and/or irradiation were significantly lower than the corresponding SD-fed groups. Morphometric results revealed that gastric, ileal and colonic injuries were less in IED-treated IR or IR + 5-FU + IED groups, as compared to SD-fed groups. However, IED did not alter DNA fragmentation ratios. Conclusion: Prophylactic feeding of IED has a protective effect on chemoradiation-induced gastrointestinal injury, which appears to involve the eradication of bacterial overgrowth.
dc.identifier.doi10.3109/09553002.2010.487026
dc.identifier.endpage879
dc.identifier.issn0955-3002
dc.identifier.issn1362-3095
dc.identifier.issue10en_US
dc.identifier.pmid20653343
dc.identifier.scopus2-s2.0-77957737513
dc.identifier.scopusqualityQ2
dc.identifier.startpage867
dc.identifier.urihttps://doi.org/10.3109/09553002.2010.487026
dc.identifier.urihttps://hdl.handle.net/20.500.11776/6819
dc.identifier.volume86
dc.identifier.wosWOS:000282519100007
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAral, Cenk
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofInternational Journal of Radiation Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCauses Bacterial Translocation
dc.subjectPelvic Radiotherapy
dc.subjectEnteral Nutrition
dc.subjectRadiation Enteritis
dc.subjectProctitis Syndrome
dc.subjectCancer-Patients
dc.subjectGut Microflora
dc.subjectBlood-Flow
dc.subjectArginine
dc.subjectGlutamine
dc.titleProphylactic feeding with immune-enhanced diet ameliorates chemoradiation-induced gastrointestinal injury in rats
dc.typeArticle

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