Phenolic compounds from Trifolium echinatum Bieb. and investigation of their tyrosinase inhibitory and antioxidant activities

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dc.authorid0000-0001-8932-4535
dc.authorid0000-0003-4384-4265
dc.authorid0000-0002-7946-6545
dc.authorid0000-0002-7946-6545
dc.authorscopusid6505866652
dc.authorscopusid26029065100
dc.authorscopusid7102665882
dc.authorscopusid7006671101
dc.authorwosidÖztürk, Mehmet/W-4649-2017
dc.authorwosidSABUDAK, Temine/AAG-6784-2019
dc.authorwosidTopcu, Gulacti/C-8344-2015
dc.authorwosidTopcu, Gulacti/AAH-8305-2019
dc.contributor.authorŞabudak, Temine
dc.contributor.authorDemirkıran, Özlem
dc.contributor.authorÖztürk, Mehmet
dc.contributor.authorTopçu, Gülaçtı
dc.date.accessioned2022-05-11T14:29:51Z
dc.date.available2022-05-11T14:29:51Z
dc.date.issued2013
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractTwo bischromones, 3,3'-dimethoxy-2'-oxychromone (1), 3,3'-dihydroxy-2,2'-oxychromone (2) and a biflavone, 5,7,4',5 '',3''',4''''-hexahydroxy-3 ''-O-beta-glucosyl-3',7 ''-O-biflavone (3) have been isolated from whole plant of Trifolium echinatum Bieb. together with five known fiavonoids. The structures of the compounds were elucidated by 1D and 2D NMR analysis as well as HRESIMS. The isolated compounds were investigated for their antioxidant activity and tyrosinase inhibitory activity. Highly potent inhibition was found for compounds 1 (IC50 = 0.41 mM), 5 (IC50 = 0.47 mM) and 8 (IC50 = 0.45 mM) compared to those of standard tyrosinase inhibitors kojic acid (IC50= 0.67 mM) and L-mimosine (IC50 = 0.64 mM). The antioxidative effect of the extracts was determined by using beta-carotene-linoleic acid, DPPH. scavenging, ABTS(+-) scavenging, and CUPRAC assays. The experimental findings indicated that the compounds 2 and 8 were found to be active in radical scavenging and CUPRAC assays. (C) 2013 Elsevier Ltd. All rights reserved.
dc.description.sponsorshipTUBITAK (The Scientific and Technological Research Council of Turkey)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [108T779]
dc.description.sponsorshipWe thank to TUBITAK (The Scientific and Technological Research Council of Turkey) for financial support (project number: 108T779).
dc.identifier.doi10.1016/j.phytochem.2013.08.014
dc.identifier.endpage311
dc.identifier.issn0031-9422
dc.identifier.pmid24070617
dc.identifier.scopus2-s2.0-84888341067
dc.identifier.scopusqualityQ1
dc.identifier.startpage305
dc.identifier.urihttps://doi.org/10.1016/j.phytochem.2013.08.014
dc.identifier.urihttps://hdl.handle.net/20.500.11776/7154
dc.identifier.volume96
dc.identifier.wosWOS:000328869500031
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorŞabudak, Temine
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofPhytochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFabaceae
dc.subjectTrifolium echinatum
dc.subjectBischromone
dc.subjectBiflavonoid
dc.subjectTyrosinase inhibition
dc.subjectAntioxidant activity
dc.subjectIdentification
dc.subjectSpectroscopy
dc.subjectComponents
dc.subjectPlant
dc.subjectMs
dc.titlePhenolic compounds from Trifolium echinatum Bieb. and investigation of their tyrosinase inhibitory and antioxidant activities
dc.typeArticle

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