First order derivative spectrophotometric method for the determination of benidipine hydrochloride pharmaceutical preparations and forced degradation study

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dc.authorid0000-0003-2759-4411
dc.authorscopusid55235059200
dc.authorwosidkarasakal, ayca/ABA-4762-2020
dc.contributor.authorKarasakal, Ayça
dc.date.accessioned2022-05-11T14:30:52Z
dc.date.available2022-05-11T14:30:52Z
dc.date.issued2015
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractA simple and rapid first order derivative spectrophotometric method was developed for the determination of benidipine hydrochloride in pure form and pharmaceutical preparations. For the first derivative spectrophotometric method, the distances between two extremum values l (peak-to-peak amplitudes), 230.2/241.5 nm. The proposed method was validated according to the ICH guidelines with respect to linearity, limit of detection, limit of quantification, accuracy, precision (intra- and inter-day) and recovery were evaluated. The linearity of the method was in the range of 0.2-2.0 mu g/mL. Limits of detection and quantification were 0.58 and 1.73 mu g/mL, respectively. The proposed method was successfully applied to the analysis of pharmaceutical preparations. In addition, forced degradation studies were performed on the benidipine hydrochloride drag substance. The drug substance was exposed to the stress conditions of hydrolysis (acid and base).
dc.description.sponsorshipResearch Fund of the University of Namik Kemal UniversityNamik Kemal University [NKUBAP.00.24.AR.13.08]
dc.description.sponsorshipThis work was supported by the Research Fund of the University of Namik Kemal University (NKUBAP.00.24.AR.13.08).
dc.identifier.doi10.1134/S0030400X1506003X
dc.identifier.endpage1006
dc.identifier.issn0030-400X
dc.identifier.issn1562-6911
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-84932632412
dc.identifier.scopusqualityQ4
dc.identifier.startpage1002
dc.identifier.urihttps://doi.org/10.1134/S0030400X1506003X
dc.identifier.urihttps://hdl.handle.net/20.500.11776/7202
dc.identifier.volume118
dc.identifier.wosWOS:000356931100022
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorKarasakal, Ayça
dc.language.isoen
dc.publisherPleiades Publishing Inc
dc.relation.ispartofOptics and Spectroscopy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHuman Plasma
dc.titleFirst order derivative spectrophotometric method for the determination of benidipine hydrochloride pharmaceutical preparations and forced degradation study
dc.typeArticle

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