The effect of low molecular weight heparin on salvaging the zone of stasis in an experimental burn model

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dc.authorid0000-0002-3129-8255
dc.authorscopusid12797300800
dc.authorscopusid17135370200
dc.authorscopusid35291638400
dc.authorscopusid6701582136
dc.authorscopusid6602860479
dc.authorwosidLivaoğlu, Murat/AAR-4663-2020
dc.authorwosidKaracal, Naci/AAL-5562-2021
dc.authorwosidersöz, safak/AAM-9041-2021
dc.contributor.authorUraloğlu, Muhammet
dc.contributor.authorLivaoğlu, Murat
dc.contributor.authorAğdoğan, Özgür
dc.contributor.authorErsöz, Şafak
dc.contributor.authorKaraçal, Naci
dc.date.accessioned2022-05-11T14:36:53Z
dc.date.available2022-05-11T14:36:53Z
dc.date.issued2018
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Plastik, Rekonstrüktif ve Estetik Cerrahi Ana Bilim Dalı
dc.description.abstractBackground/aim: Multiple zones of injuries are formed after burns, consisting of a zone of coagulative necrosis, a zone of hyperemia, and a zone of stasis, in which progressive microcirculatory thrombosis leads to degeneration and deepening of the wound. We used an experimental rat comb burn model to test the hypothesis that use of low molecular weight heparin (LMWH) may save the zone of stasis. Materials and methods: Adult female rats were randomly divided two groups: the LMWH group (n = 8) rats received subcutaneous LMWH injections, while the saline group (n = 8) rats were injected with the same volume of saline solution by the same route. The zone of stasis was evaluated macroscopically and histologically, and functional capillary density was evaluated. Results: Histological assessments revealed higher macrophage numbers and PML density, fibroblast proliferation, and angiogenesis in the LMWH group than in the saline group. Functional capillary density measurement in the stasis zones revealed no significant difference between the two groups in the first 4 days, although a significant difference in favor of the LMW group was observed in the last 3 days. Conclusion: The results of this experimental study show that LMWH is effective in saving the zone of stasis.
dc.identifier.doi10.3906/sag-1710-73
dc.identifier.endpage660
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue3en_US
dc.identifier.pmid29916226
dc.identifier.scopus2-s2.0-85048643224
dc.identifier.scopusqualityQ3
dc.identifier.startpage653
dc.identifier.urihttps://doi.org/10.3906/sag-1710-73
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8455
dc.identifier.volume48
dc.identifier.wosWOS:000435653900029
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAğdoğan, Özgür
dc.language.isoen
dc.publisherTubitak Scientific & Technical Research Council Turkey
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectLow molecular weight heparin
dc.subjectburn
dc.subjectstasis zone
dc.subjectThermal-Injury
dc.subjectVascular-Response
dc.subjectRat Model
dc.subjectMicrocirculation
dc.subjectProgression
dc.subjectPrevention
dc.subjectViability
dc.subjectIschemia
dc.subjectTherapy
dc.subjectCell
dc.titleThe effect of low molecular weight heparin on salvaging the zone of stasis in an experimental burn model
dc.typeArticle

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