Longitudinal Study of Cognitive Impairment in Multiple Sclerosis: A 5-year Follow-up

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dc.authorscopusid24464301600
dc.authorscopusid56572293600
dc.authorscopusid16069377400
dc.authorscopusid16041076900
dc.authorscopusid6507483599
dc.contributor.authorKuşcu, Demet Yandim
dc.contributor.authorKandemir, Melek
dc.contributor.authorÜnal, Aysun
dc.contributor.authorTopcular, Baris
dc.contributor.authorKırbaş, Dursun
dc.date.accessioned2022-05-11T14:40:13Z
dc.date.available2022-05-11T14:40:13Z
dc.date.issued2012
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractObjectives: Cognitive impairment can be demonstrated in 40 to 65% of MS patients, starting from early stages. The aim of this study was to investigate alteration in cognitive impairment during long-term follow-up and the association with the disease characteristics. Method: Twenty-five MS patients (15 men, 10 women) were reexamined after an average of 5.3 years (range: 4.9-5.8). The disease duration, type, Expanded Disability Status Scale (EDSS) scores at the initial and last evaluations were recorded. They underwent a comprehensive neuropsychological evaluation. Major depression was excluded. Results: The mean age of the patients was 39.2 +/- 9.3 years and the mean duration of the disease was 11.4 +/- 5.14 years. The mean EDSS score at the beginning and last follow-up were 2.92 +/- 1.52 and 3.56 +/- 1.92, respectively. At the end of the follow-up period, the patients performed poorly on the Corsi Block-Tapping Test (p<0.001) and there was a significant difference in maximum word line in the verbal memory processes test (VMPT) (p<0.001). Short-term memory scores, assessed with the Wechsler Memory Scale (WMS), decreased slightly, but the total recall score was significantly worse (p<0.001). There was also significant decrease in executive functions according to the stroop test (p<0.001), and the Wisconsin Card Sorting Test (WCST) results in patients with a longer disease course were worse. Besides, there was a trend for worsening in the clock-drawing test. The language skills were well preserved. Patients with a disease duration of >= 10 years scored worse on the stroop test, clock-drawing test, Benton Line Orientation Test (BLOT), WCST, and VMPT. Discussion: The cognitive deficits tended to worsen during long-term follow-up. There was no correlation between severity of disability and cognitive impairment. However, there seems to be an association between results of some tests and disease duration. (Archives of Neuropsychiatry 2012;49: 29-32)
dc.identifier.doi10.4274/npa.y6088
dc.identifier.endpage32
dc.identifier.issn1300-0667
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84861786479
dc.identifier.scopusqualityQ3
dc.identifier.startpage29
dc.identifier.urihttps://doi.org/10.4274/npa.y6088
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8908
dc.identifier.volume49
dc.identifier.wosWOS:000302187200005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorÜnal, Aysun
dc.language.isoen
dc.publisherGalenos Yayincilik
dc.relation.ispartofNoropsikiyatri Arsivi-Archives of Neuropsychiatry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMultiple sclerosis
dc.subjectcognitive impairment
dc.subjectcognitive dysfunction
dc.subjectneuropsychological evaluation
dc.subjectDysfunction
dc.titleLongitudinal Study of Cognitive Impairment in Multiple Sclerosis: A 5-year Follow-up
dc.title.alternativeMultipl Sklerozda Kognitif Etkilenme; 5 Yıllık Takip Çalışması]
dc.typeArticle

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