Generation of Silk Fibroin-Ca-P Composite Biomimetic Bone Replacement Material Using Electrochemical Deposition

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dc.authorid0000-0002-5143-3602
dc.contributor.authorUtku, Feride Şermin
dc.contributor.authorBaşaran, Kübra
dc.contributor.authorSunar, Yağmur
dc.contributor.authorÇelebioğlu, Hülya
dc.contributor.authorKapıcı, İbrahim
dc.date.accessioned2022-05-11T14:16:03Z
dc.date.available2022-05-11T14:16:03Z
dc.date.issued2017
dc.departmentFakülteler, Çorlu Mühendislik Fakültesi, Biyomedikal Mühendisliği Bölümü
dc.description.abstractMineralized natural protein based novel bone replacement materials are investigated for tissue engineering. Mineralized silk fibroin composite foams and films display excellent biocompatibility. In this study, the biomimetic and electrochemical mineralization of orderly oriented silk fibroin scaffolds was studied. Commercially obtained pure silk woven fabric was boiled in 0.02 M Na2CO3 for 20 min. Calcium phosphate was deposited at 37 degrees C for twenty minutes in seven sequential immersion steps, using 250 mM CaCl2 2H(2)O and 120 mM K2HPO4, containing 0.15 M NaCl and 50 mM TRIS-HCl, pH 7.4, followed by electrochemical treatment in modified SBF solution at 40 degrees C at a current density of -25mA/cm(2) for 60 min. The amount of biomimetically deposited Ca-P increased with the number of immersion steps. SEM images and XRD analysis of the Ca-P deposit indicated the initial formation of brushite with its monoclinic crystal structure and characteristic peak at 11.76 2 theta, and electrochemical conversion of brushite to hydroxyapatite on silk after electrochemical cathodization as confirmed by XRD and SEM analysis. Thus, a silk-fibroin-hydroxyapatite composite material prepared as a xenograft consisting of biocompatible components, and easily prepared as an economical bone segment replacement material with highly oriented fibers.
dc.identifier.issn1303-0914
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85028014431
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://hdl.handle.net/20.500.11776/6163
dc.identifier.volume17
dc.identifier.wosWOS:000411067100017
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorSunar, Yağmur
dc.institutionauthorÇelebioğlu, Hüly
dc.language.isoen
dc.publisherIstanbul Univ, Fac Engineering
dc.relation.ispartofIstanbul University-Journal of Electrical and Electronics Engineering
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectsilk-fibroin-hydroxyapatite scaffold
dc.subjectcomposite biomaterials
dc.subjectbone tissue engineering
dc.subjectbone replacement materials
dc.subjectIn-Vitro
dc.subjectScaffolds
dc.subjectHydroxyapatite
dc.subjectBiomaterials
dc.subjectCrystals
dc.titleGeneration of Silk Fibroin-Ca-P Composite Biomimetic Bone Replacement Material Using Electrochemical Deposition
dc.typeArticle

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