Omentin and chemerin and their association with obesity in women with polycystic ovary syndrome

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dc.authorscopusid42661653300
dc.authorscopusid24075279000
dc.authorscopusid6506061779
dc.authorscopusid55481926000
dc.authorscopusid55597937800
dc.authorscopusid56354902200
dc.authorscopusid57197051921
dc.contributor.authorGüzel, Eda Çelik
dc.contributor.authorÇelik, Cem
dc.contributor.authorAbalı, Remzi
dc.contributor.authorKüçükyalçın, Volkan
dc.contributor.authorÇelik, Elcin
dc.contributor.authorGüzel, Murat
dc.contributor.authorYılmaz, Murat
dc.date.accessioned2022-05-11T14:10:12Z
dc.date.available2022-05-11T14:10:12Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Aile Hekimliği Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractWe aimed to investigate whether overweight/obesity is associated with omentin and chemerin. The study group consisted of 81 women with Polycystic ovarian syndrome (PCOS) (41 lean, BMI<25 kg/m(2) and 40 overweight or obese, BMI>25 kg/m(2)) and 61 healthy subjects (31 lean, BMI<25 kg/m(2) and 30 overweight or obese, BMI>25 kg/m(2); control group). The clinical, endocrine, metabolic parameters, plasma omentin and chemerin levels were measured in patients and compared to control. In all subjects with PCOS (n = 80), serum chemerin levels were higher compared with those of the controls (n = 58) (7.71 +/- 1.78 ng/mL versus 6.94 +/- 0.82 ng/mL, p = 0.003). However, serum omentin levels were not significantly different between the PCOS subjects and the controls (1.55 +/- 0.43 ng/mL versus 1.69 +/- 0.37 ng/mL, p = 0.056). The mean chemerin concentrations were significantly elevated in the obese PCOS group compared with the obese control subjects (8.98 +/- 1.45 ng/mL versus 7.02 +/- 0.67 ng/mL, p = 0.000) and the nonobese PCOS group compared with the obese control subjects (6.57 +/- 1.17 ng/mL versus 7.02 +/- 0.67 ng/mL, p = 0.000). In conclusion, fat mass seems to be the main determinant factor of increased chemerin and decreased omentin in women with PCOS.
dc.description.sponsorshipNamik Kemal UniversityNamik Kemal University
dc.description.sponsorshipThe contribution of all authors and project partners is acknowledged, along with the support of Namik Kemal University.
dc.identifier.doi10.3109/09513590.2014.888412
dc.identifier.endpage422
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.issue6en_US
dc.identifier.pmid24524360
dc.identifier.scopus2-s2.0-84901217478
dc.identifier.scopusqualityQ2
dc.identifier.startpage419
dc.identifier.urihttps://doi.org/10.3109/09513590.2014.888412
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5322
dc.identifier.volume30
dc.identifier.wosWOS:000336790400005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGüzel, Eda Çelik
dc.institutionauthorÇelik, Cem
dc.institutionauthorAbalı, Remzi
dc.institutionauthorGuzel, Murat
dc.institutionauthorYilmaz, Murat
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofGynecological Endocrinology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAndrogen
dc.subjectchemerin
dc.subjectinsulin resistance
dc.subjectomentin
dc.subjectpolycystic ovary syndrome
dc.subjectImpaired Glucose-Tolerance
dc.subjectInsulin-Resistance
dc.subjectMetabolic Syndrome
dc.subjectAdipose-Tissue
dc.subjectWeight-Loss
dc.subjectPrevalence
dc.subjectSensitivity
dc.subjectAdiponectin
dc.subjectPredictors
dc.subjectSecretion
dc.titleOmentin and chemerin and their association with obesity in women with polycystic ovary syndrome
dc.typeArticle

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