Omentin and chemerin and their association with obesity in women with polycystic ovary syndrome
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Dosyalar
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
We aimed to investigate whether overweight/obesity is associated with omentin and chemerin. The study group consisted of 81 women with Polycystic ovarian syndrome (PCOS) (41 lean, BMI<25 kg/m(2) and 40 overweight or obese, BMI>25 kg/m(2)) and 61 healthy subjects (31 lean, BMI<25 kg/m(2) and 30 overweight or obese, BMI>25 kg/m(2); control group). The clinical, endocrine, metabolic parameters, plasma omentin and chemerin levels were measured in patients and compared to control. In all subjects with PCOS (n = 80), serum chemerin levels were higher compared with those of the controls (n = 58) (7.71 +/- 1.78 ng/mL versus 6.94 +/- 0.82 ng/mL, p = 0.003). However, serum omentin levels were not significantly different between the PCOS subjects and the controls (1.55 +/- 0.43 ng/mL versus 1.69 +/- 0.37 ng/mL, p = 0.056). The mean chemerin concentrations were significantly elevated in the obese PCOS group compared with the obese control subjects (8.98 +/- 1.45 ng/mL versus 7.02 +/- 0.67 ng/mL, p = 0.000) and the nonobese PCOS group compared with the obese control subjects (6.57 +/- 1.17 ng/mL versus 7.02 +/- 0.67 ng/mL, p = 0.000). In conclusion, fat mass seems to be the main determinant factor of increased chemerin and decreased omentin in women with PCOS.
Açıklama
Anahtar Kelimeler
Androgen, chemerin, insulin resistance, omentin, polycystic ovary syndrome, Impaired Glucose-Tolerance, Insulin-Resistance, Metabolic Syndrome, Adipose-Tissue, Weight-Loss, Prevalence, Sensitivity, Adiponectin, Predictors, Secretion
Kaynak
Gynecological Endocrinology
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
30
Sayı
6
