Protective effect of Spirulina platensis against cell damage and apoptosis in hepatic tissue caused by high fat diet

dc.authorid0000-0002-1589-9229
dc.authorid0000-0001-9444-3598
dc.authorid0000-0002-7359-6568
dc.authorid0000-0001-7258-6862
dc.authorscopusid35788331200
dc.authorscopusid57115408300
dc.authorscopusid57126277600
dc.authorscopusid55834779800
dc.authorscopusid6603862675
dc.authorscopusid22934953000
dc.authorscopusid55971756000
dc.authorwosidGurevin, Ebru Gurel/AAC-7921-2020
dc.authorwosidESENER, Osman Behzat Burak/D-1598-2019
dc.authorwosidArmutak, Elif/D-2901-2019
dc.authorwosidBilal, Tanay/D-2596-2019
dc.authorwosidBILAL, TANAY/AAB-5566-2021
dc.contributor.authorYiğit, Funda
dc.contributor.authorGürel Gürevin, Ebru
dc.contributor.authorİşbilen Başok, Banu
dc.contributor.authorEsener, Osman Behzat Burak
dc.contributor.authorBilal, T.
dc.contributor.authorKeser, O.
dc.contributor.authorİkitimur Armutak, Elif
dc.contributor.authorYılmazer, N.
dc.date.accessioned2022-05-11T14:28:34Z
dc.date.available2022-05-11T14:28:34Z
dc.date.issued2016
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Biyoloji Bölümü
dc.description.abstractSpirulina platensis is a microalga that may be a source of antioxidants that can reduce body fat deposition. Consumption of a high fat diet produces elevated blood lipid levels, inflammation and apoptosis. We investigated the possible effects of S. platensis on the blood lipid profile, and liver inflammation and apoptosis in rats fed a high fat diet. Sixty-four young male rats were divided into eight equal groups. The control group was fed a basic diet. The experimental groups were fed a diet for 60 days that was prepared by mixing variable amounts of 43% vegetable oil and 10% cholesterol with or without 3% S. platensis mixed with the basal diet. Blood and liver tissue samples were collected from each animal. Serum samples were used to analyze lipid parameters, total antioxidant status and total oxidant status. iNOS and eNOS were determined by immunohistochemistry. TUNEL staining was used to detect apoptosis to investigate a possible connection between inflammation and apoptosis in the liver tissue. The relations between fat deposition and liver degeneration were assessed by Sirius red staining and alpha-smooth muscle actin immunostaining. S. platensis reduced serum HDL-C, LDL-C and triglyceride, increased HDL-C levels in rats fed a high fat diet to near control levels, and reduced iNOS levels and increased eNOS levels in the liver tissue compared to vegetable oil and cholesterol treated groups. The apoptotic index was reduced in the groups that were fed a high fat or a basic diet when supplemented with S. platensis.
dc.identifier.doi10.3109/10520295.2015.1114142
dc.identifier.endpage194
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue3en_US
dc.identifier.pmid26820259
dc.identifier.scopus2-s2.0-84958534865
dc.identifier.scopusqualityQ2
dc.identifier.startpage182
dc.identifier.urihttps://doi.org/10.3109/10520295.2015.1114142
dc.identifier.urihttps://hdl.handle.net/20.500.11776/6876
dc.identifier.volume91
dc.identifier.wosWOS:000372898400004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYılmazer, Nadim
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofBiotechnic & Histochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjecthigh fat diet
dc.subjectiNOS
dc.subjectliver
dc.subjecteNOS
dc.subjectSpirulina platensis
dc.subjectapoptosis
dc.subjectNitric-Oxide Synthase
dc.subjectSmooth-Muscle-Actin
dc.subjectLiver-Disease
dc.subjectOxidative Stress
dc.subjectC-Phycocyanin
dc.subjectAntiinflammatory Activity
dc.subjectGene-Expression
dc.subjectBeta-Carotene
dc.subjectFree-Radicals
dc.subjectGrowth-Factor
dc.titleProtective effect of Spirulina platensis against cell damage and apoptosis in hepatic tissue caused by high fat diet
dc.typeArticle

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