The effect of papaverine on tendon healing and adhesion in rats following Achilles tendon repair

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dc.authoridArslan, Yunus Ziya/0000-0002-1861-9368
dc.authoridDincel, Yasar Mahsut/0000-0001-6576-1802
dc.contributor.authorCan, Erdem
dc.contributor.authorDincel, Yasar Mahsut
dc.contributor.authorKarabulut, Derya
dc.contributor.authorKarabag, Sevil
dc.contributor.authorArslan, Yunus Ziya
dc.date.accessioned2024-10-29T17:59:46Z
dc.date.available2024-10-29T17:59:46Z
dc.date.issued2024
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractObjectives: The study aimed to examine the histopathological and biomechanical effects of papaverine administered intraperitoneally and locally on Achilles tendon healing in a rat model. Materials and methods: Forty-eight adult male SpragueDawley rats (range, 300 to 400 g) were used in this study conducted between October and November 2022. The rats were divided into three groups, with each group further subdivided into two for sacrifice on either the 15(th) (early period) or 30(th) (late period) day after surgery. The first (control) group received no treatment following Achilles tendon repair, while papaverine was intraperitoneally administered every other day for 10 days in the second group and locally in the third group after surgery. On the 15(th) and 30(th) days, the rats were sacrificed, and their Achilles tendons were subjected to biomechanical testing and histopathological evaluation. Results: Histopathologically, there were no significant differences among the groups on the 15 th day. However, on the 30 th day, the locally applied papaverine group exhibited superior histopathological outcomes compared to the control group (p<0.05). Concerning the highest tensile strength values before rupture, the biomechanical assessment showed that the group receiving local papaverine treatment in the early period and both the group with systemic papaverine treatment and the one with local papaverine treatment in the late period displayed a statistically significant advantage compared to the control group (p<0.05). Conclusion: Locally administered papaverine has positive biomechanical effects in the early period and exhibits a positive correlation both histopathologically and biomechanically in the late period. Novel therapeutic options may be provided for patients through these findings.
dc.identifier.doi10.52312/jdrs.2024.1656
dc.identifier.endpage376
dc.identifier.issn2687-4792
dc.identifier.issue2en_US
dc.identifier.pmid38727117
dc.identifier.scopus2-s2.0-85192847901
dc.identifier.scopusqualityQ2
dc.identifier.startpage368
dc.identifier.trdizinid#BAŞV!
dc.identifier.urihttps://doi.org/10.52312/jdrs.2024.1656
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1257542
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14832
dc.identifier.volume35
dc.identifier.wosWOS:001218338700031
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Joint Diseases Foundation
dc.relation.ispartofJoint Diseases and Related Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAchilles tendon
dc.subjecthealing
dc.subjectpapaverine
dc.subjectrat
dc.subjecttendon repair
dc.titleThe effect of papaverine on tendon healing and adhesion in rats following Achilles tendon repair
dc.title.alternativeThe effect of papaverine on tendon healing and adhesion in rats following Achilles tendon repair
dc.typeArticle

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