In vitro analysis of a novel controlled release system designed for intratympanic administration of N-acetylcysteine: a preliminary report

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dc.authorid0000-0003-3307-085X
dc.authorid0000-0003-2003-6337
dc.authorscopusid55078843000
dc.authorscopusid15055538600
dc.authorscopusid35197435300
dc.authorscopusid56763778100
dc.authorscopusid56769801000
dc.authorscopusid26648338400
dc.authorwosidCiftci, Zafer/AAW-9972-2021
dc.authorwosidsirin, duygu yasar/AAR-8685-2020
dc.authorwosidYILMAZ, Ibrahim/H-6199-2019
dc.contributor.authorÇiftçi, Zafer
dc.contributor.authorDeniz, Mahmut
dc.contributor.authorYılmaz, İbrahim
dc.contributor.authorÇiftçi, Halide Güneş
dc.contributor.authorŞirin, Duygu Yaşar
dc.contributor.authorGültekin, Erdoğan
dc.date.accessioned2022-05-11T14:12:15Z
dc.date.available2022-05-11T14:12:15Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kulak Burun ve Boğaz Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Biyoloji Bölümü
dc.description.abstractThe aim of this in-vitro experimental study was to design a novel drug delivery system that may permit controlled release of N-acetylcysteine (NAC) following intratympanic administration. The system was composed of two different solutions that attained a hydrogel form within seconds after getting into contact with each other. The authors performed swelling, pH and temperature tests and analysis of. controlled release of NAC from this novel controlled release system. For the structure and porosity analysis of the hydrogel, an environmental scanning electron microscope (SEM) was used. The diameter of designed hydrogel showed an increase when pH was increased. In addition, in comparison to acidic values, the pore diameter of the hydrogel increased significantly especially in physiological level. The increase in the pore diameter was also directly proportional to the increase in temperature. Spectrophotometric analysis showed that the amount of NAC released into the medium was statistically significant (p = 0.038, t = 2.18, 95% CI; DF: 27). SEM analysis of the samples revealed a smooth surface topography and numerous porous structures. The authors are of the opinion that the designed hydrogel may be used as an alternative method for invatympanic delivery of NAC for otoprotective purposes. The disadvantages of intratympanic injection of the drug in its liquid form, including leakage through eustachian tube, restraining the patient in an uncomfortable position, necessity for repetitive injections and dose dependent inflammation of the middle ear epithelium, may also be avoided. Further in vivo studies should be conducted to assess its tolerability and effectivity. (C) 2015 Elsevier Inc. All rights reserved.
dc.identifier.doi10.1016/j.amjoto.2015.08.004
dc.identifier.endpage793
dc.identifier.issn0196-0709
dc.identifier.issn1532-818X
dc.identifier.issue6en_US
dc.identifier.pmid26545472
dc.identifier.scopus2-s2.0-84949653998
dc.identifier.scopusqualityQ1
dc.identifier.startpage786
dc.identifier.urihttps://doi.org/10.1016/j.amjoto.2015.08.004
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5470
dc.identifier.volume36
dc.identifier.wosWOS:000364801900012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÇiftçi, Zafer
dc.institutionauthorDeniz, Mahmut
dc.institutionauthorŞirin, Duygu Yaşar
dc.institutionauthorGültekin, Erdoğan
dc.language.isoen
dc.publisherW B Saunders Co-Elsevier Inc
dc.relation.ispartofAmerican Journal of Otolaryngology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCisplatin-Induced Ototoxicity
dc.subjectInduced Hearing-Loss
dc.subjectInner-Ear
dc.subjectGuinea-Pigs
dc.subjectDelivery-System
dc.subjectProtective Role
dc.subjectRat Model
dc.subjectHydrogel
dc.subjectDexamethasone
dc.subjectPrevention
dc.titleIn vitro analysis of a novel controlled release system designed for intratympanic administration of N-acetylcysteine: a preliminary report
dc.typeArticle

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