The influence of phytogenic additive on the antioxidant capacity, immunity and liver functions in stress-induced male rats

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dc.authoridKOSELI, EDA/0000-0002-4812-4024
dc.authoridSeyidoglu, Nilay/0000-0002-2817-5131
dc.authorwosidKOSELI, EDA/GRJ-2026-2022
dc.contributor.authorKöşeli, E.
dc.contributor.authorSeyidoğlu, Nilay
dc.contributor.authorGurbanlı, R.
dc.contributor.authorAydın, C.
dc.date.accessioned2023-05-06T17:23:37Z
dc.date.available2023-05-06T17:23:37Z
dc.date.issued2022
dc.departmentFakülteler, Veteriner Fakültesi, Temel Bilimler Bölümü, Fizyoloji Ana Bilim Dalı
dc.description.abstractGlobal animal feeding strategies have been modified due to several ecosystem changes that cause stress and decline in health, growth, and yields.According to the literature, natural additives have been fundamental to animal health from day to day. The present study measured changes in antioxidant status, immunity, liver functions and organ weights tested under stress conditions to determine whether dietary supplementation with phytogenic additive could provide beneficial effects. Forty-eight adult,male Sprague-Dawley rats were randomly separated into four groups;-Control(C),Stress(S),Treatment(Tr),Treatment and Stress(TrS). Rats in groups Tr and TrS received phytogenic additive by adding into water (2mL/L) 5days a week for 28days. All rats were exposed to prolonged light phase conditions (18h light: 6h dark) for 14 days. Also, two chronic stresses, isolation and crowded environments, were applied to animals in the Stress and TrS groups. There was a significant decline in the oxidant status in untreated stress group, while phytogenic additive fed rats maintained a significantly higher total antioxidant status. This study also showed a significant increase in IL-4 and decrease in IFN-gamma in the untreated Stress group compared to the Control group. There were increases in liver enzymes in the Stress group in comparison to the Control group. After the phytogenic treat-ment, there was an increase in the weight of the liver, intestine, brain and testes. In conclusion, this study showed that supplementation of phytogenic additive containing milk thistle and artichoke with choline,carnitine, vitamin E and methionine describes the protective effects on antioxidant status, immunological parameters and liver functions under mixed stress conditions.
dc.identifier.doi10.12681/jhvms.27432
dc.identifier.endpage4458
dc.identifier.issn1792-2720
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85141787182
dc.identifier.scopusqualityQ3
dc.identifier.startpage4449
dc.identifier.urihttps://doi.org/10.12681/jhvms.27432
dc.identifier.urihttps://hdl.handle.net/20.500.11776/12196
dc.identifier.volume73
dc.identifier.wosWOS:000877557800019
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorSeyidoğlu, Nilay
dc.language.isoen
dc.publisherHellenic Veterinary Medical Soc
dc.relation.ispartofJournal Of The Hellenic Veterinary Medical Society
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntioxidant status
dc.subjectfeed additives
dc.subjectimmunity
dc.subjectphytogenic ingredients
dc.subjectstress
dc.subjectrats
dc.subjectOxidative Stress
dc.subjectPsychological Stress
dc.subjectGrowth-Performance
dc.subjectStocking Density
dc.subjectPhotoperiod
dc.subjectMicrobiota
dc.subjectCytokine
dc.titleThe influence of phytogenic additive on the antioxidant capacity, immunity and liver functions in stress-induced male rats
dc.typeArticle

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