GENETIC DIVERSITY of OVINE HERPESVIRUS 2 STRAINS OBTAINED FROM MALIGNANT CATARRHAL FEVER CASES in EASTERN TURKEY

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dc.authorid0000-0002-5811-2588
dc.authorid0000-0002-3712-7991
dc.authorid0000-0002-5080-1936
dc.authorscopusid57209063248
dc.authorscopusid13103100800
dc.authorscopusid57205634231
dc.authorscopusid55266555300
dc.authorscopusid7003605484
dc.authorwosidBulut, Hakan/ABA-1433-2020
dc.authorwosidTURAN, Turhan/ABI-4192-2020
dc.authorwosidIŞIDAN, Hakan/AAA-1666-2020
dc.authorwosidsozdutmaz, ibrahim/I-7358-2015
dc.contributor.authorTuran, Turhan
dc.contributor.authorIşıdan, Hakan
dc.contributor.authorAtasoy, Mustafa Ozan
dc.contributor.authorSözdutmaz, İbrahim
dc.contributor.authorBulut, Hakan
dc.date.accessioned2022-05-11T14:42:22Z
dc.date.available2022-05-11T14:42:22Z
dc.date.issued2020
dc.departmentFakülteler, Veteriner Fakültesi, Klinik Öncesi Bilimler Bölümü, Viroloji Ana Bilim Dalı
dc.description.abstractMalignant Catarrhal Fever (MCF) is a generalized, definitive lethal disease affecting the epithelial and lymphoid tissues of the respiratory and digestive tract, mainly cattle and some wild ruminants such as deer, buffalo or antelope. The sheep-related form of MCF is known to be present in Turkey and is caused by ovine herpesvirus 2 (OvHV-2). The aim of this study was to reveal the genetic diversity of OvHV-2 strains obtained from MCF cases in Eastern Turkey where the livestock industry has an important impact on economic activities. For this purpose, RTA (Replication and transcription activator), FGARAT (formylglycineamide ribotide amidotransferase) and some of glycoprotein genes (0v7, Ov8 ex2, ORF27 and Ov9.5) were investigated in blood samples from 24 cattles, clinically diagnosed with MCF. Genomic data of chosen samples were furthermore used to characterize and undergo combined phylogenetic analysis to determine possible alleles and subvariants. The results showed that high level of OvHV-2 diversity existed in selected genes and strains carrying allelic variants might circulate both in two geographically distinct regions and in a region itself. Moreover, three different OvHV-2 types and various subtypes were identified based on multi locus approach. This study provides important data to epidemiological research and thereby helps to determine the source of the virus and understand the spread of the disease.
dc.identifier.doi10.1016/j.virusres.2019.197801
dc.identifier.issn0168-1702
dc.identifier.issn1872-7492
dc.identifier.pmid31722243
dc.identifier.scopus2-s2.0-85076053240
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.virusres.2019.197801
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9348
dc.identifier.volume276
dc.identifier.wosWOS:000509778600017
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBulut, Hakan
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofVirus Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMalignant catarrhal fever
dc.subjectEastern Turkey
dc.subjectMolecular characterization
dc.subjectGlycoprotein
dc.subjectFGARAT
dc.subjectRTA
dc.subjectSequence
dc.subjectRegion
dc.titleGENETIC DIVERSITY of OVINE HERPESVIRUS 2 STRAINS OBTAINED FROM MALIGNANT CATARRHAL FEVER CASES in EASTERN TURKEY
dc.typeArticle

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