Caloric restriction and redox homeostasis in various regions of aging male rat brain: Is caloric restriction still worth trying even after early-adulthood? Redox homeostasis and caloric restriction in brain

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dc.authorid0000-0001-6571-415X
dc.authorid0000-0001-9861-7380
dc.authorid0000-0003-1038-6245
dc.authorid0000-0002-8174-0515
dc.authorid0000-0001-6198-8006
dc.authorscopusid35367397500
dc.authorscopusid57196825800
dc.authorscopusid57204930061
dc.authorscopusid57204928091
dc.authorscopusid6507178805
dc.authorscopusid6602572552
dc.authorscopusid7005387035
dc.authorwosidYanar, Karolin/D-3016-2019
dc.authorwosidCakatay, Ufuk/D-2752-2015
dc.authorwosidaydın, seval/AAD-3579-2021
dc.authorwosidSimsek, Bahadir/ABA-1537-2020
dc.contributor.authorYanar, Karolin
dc.contributor.authorŞimşek, Bahadır
dc.contributor.authorÇaylı, Nisanur
dc.contributor.authorBozkır, Haktan Övül
dc.contributor.authorMengi, Murat
dc.contributor.authorBelce, Ahmet
dc.contributor.authorÇakatay, Ufuk
dc.date.accessioned2022-05-11T14:41:24Z
dc.date.available2022-05-11T14:41:24Z
dc.date.issued2019
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.description.abstractDespite recent studies have shown that caloric restriction (CR) could improve some functional loss associated with brain aging, the biochemical effects of CR on brain aging are still not well understood on a quantifiable biochemical basis, including whether CR could be protective when started around middle adulthood, when age-related neurodegenerative diseases are thought to set in. Therefore, in the light of more than ever aging societies and increasing neurodegenerative diseases, we aimed to test the biochemical effects of CR on redox homeostasis in different parts of male Sprague-Dawley rat brain by using the biomarkers we consistently validated in our previous work (TOS, PCO, AOPP, AGEs, sRAGE, P-SH, LHPs, 4-HNE, TAS, Cu, Zn-SOD). Our results indicate that oxidative stress biomarkers are lower in CR group, implying a more favorable redox status that has been previously shown to be correlated with better neural function.
dc.description.sponsorshipIstanbul UniversitesiIstanbul University [27127]
dc.description.sponsorshipIstanbul Universitesi, Grant/Award Number: 27127
dc.identifier.doi10.1111/jfbc.12740
dc.identifier.issn0145-8884
dc.identifier.issn1745-4514
dc.identifier.issue3en_US
dc.identifier.pmid31353564
dc.identifier.scopus2-s2.0-85057988665
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1111/jfbc.12740
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9168
dc.identifier.volume43
dc.identifier.wosWOS:000461068900019
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorMengi, Murat
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Food Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectaging
dc.subjectbrain lobes
dc.subjectcaloric restriction
dc.subjectoxidative stress
dc.subjectredox homeostasis
dc.subjectGlycation End-Products
dc.subjectOxidative Stress
dc.subjectDietary Restriction
dc.subjectAlzheimers-Disease
dc.subjectSoluble Receptor
dc.subjectDamage
dc.subjectAge
dc.subjectAutophagy
dc.subjectRisk
dc.subjectMetaanalysis
dc.titleCaloric restriction and redox homeostasis in various regions of aging male rat brain: Is caloric restriction still worth trying even after early-adulthood? Redox homeostasis and caloric restriction in brain
dc.typeArticle

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