Caloric restriction and redox homeostasis in various regions of aging male rat brain: Is caloric restriction still worth trying even after early-adulthood? Redox homeostasis and caloric restriction in brain
Yükleniyor...
Dosyalar
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Despite recent studies have shown that caloric restriction (CR) could improve some functional loss associated with brain aging, the biochemical effects of CR on brain aging are still not well understood on a quantifiable biochemical basis, including whether CR could be protective when started around middle adulthood, when age-related neurodegenerative diseases are thought to set in. Therefore, in the light of more than ever aging societies and increasing neurodegenerative diseases, we aimed to test the biochemical effects of CR on redox homeostasis in different parts of male Sprague-Dawley rat brain by using the biomarkers we consistently validated in our previous work (TOS, PCO, AOPP, AGEs, sRAGE, P-SH, LHPs, 4-HNE, TAS, Cu, Zn-SOD). Our results indicate that oxidative stress biomarkers are lower in CR group, implying a more favorable redox status that has been previously shown to be correlated with better neural function.
Açıklama
Anahtar Kelimeler
aging, brain lobes, caloric restriction, oxidative stress, redox homeostasis, Glycation End-Products, Oxidative Stress, Dietary Restriction, Alzheimers-Disease, Soluble Receptor, Damage, Age, Autophagy, Risk, Metaanalysis
Kaynak
Journal of Food Biochemistry
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
43
Sayı
3
