In-vitro evaluation of the effects of tigecycline on annulus firosus and nucleus pulposus

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dc.contributor.authorKaya, Yasin Emre
dc.contributor.authorYılmaz, İbrahi?m
dc.contributor.authorKaraarslan, Numan
dc.contributor.authorBilir, Bülent
dc.contributor.authorŞirin, Duygu Yaşar
dc.contributor.authorÖzbek, Hanefi
dc.date.accessioned2022-05-11T14:09:58Z
dc.date.available2022-05-11T14:09:58Z
dc.date.issued2020
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Biyoloji Bölümü
dc.description.abstractAim: This study aimed to examine the effects of tigecycline on primary cell cultures established using intervertebral disc tissues.Material and Methods: Primary Annulus Fibrosus and Nucleus Pulposus cultures were obtained from human intervertebral disctissue. Untreated samples served as the control group, and treated samples served as the study group. Treated and untreatedsamples were statistically evaluated using an alpha signifiance value of < 0.05.Results: Proliferation and gene expression decreased in the tigecycline administered cultures when compared to the control groupsamples (P < 0.05).Conclusion: Drugs used in clinics may have side effects other than those indicated in their package insert.
dc.identifier.doi10.5455/annalsmedres.2020.03.224
dc.identifier.endpage1859
dc.identifier.issn2636-7688
dc.identifier.issn2636-7688
dc.identifier.issue7en_US
dc.identifier.startpage1855
dc.identifier.trdizinidTXpjd016TTFOUT09
dc.identifier.urihttps://doi.org/10.5455/annalsmedres.2020.03.224
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TXpjd016TTFOUT09
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5228
dc.identifier.volume27
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorKaraarslan, Numan
dc.institutionauthorBilir, Bülent
dc.institutionauthorŞirin, Duygu Yaşar
dc.language.isoen
dc.relation.ispartofAnnals of Medical Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleIn-vitro evaluation of the effects of tigecycline on annulus firosus and nucleus pulposus
dc.typeArticle

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