Multiple orthonairoviruses including Crimean-Congo hemorrhagic fever virus, Tamdy virus and the novel Meram virus in Anatolia

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dc.authorid0000-0001-5008-9443
dc.authorid0000-0002-5493-0807
dc.authorid0000-0001-8185-3176
dc.authorscopusid6507415764
dc.authorscopusid26326680200
dc.authorscopusid15769247000
dc.authorscopusid57209228994
dc.authorscopusid36852282500
dc.authorscopusid57217048118
dc.authorscopusid55258915300
dc.authorwosidhacioglu, sabri/ABG-9827-2021
dc.authorwosidOzkul, Aykut/A-1973-2016
dc.authorwosidYALÇINKAYA, Deniz/ABF-8811-2020
dc.authorwosidLinton, Yvonne-Marie/AAW-3992-2021
dc.contributor.authorErgünay, Koray
dc.contributor.authorDinçer, Ender
dc.contributor.authorKar, Sırrı
dc.contributor.authorEmanet, Nergis
dc.contributor.authorYalçınkaya, Deniz
dc.contributor.authorDinçer, Pelin Fatos Polat
dc.contributor.authorLinton, Yvonne-Marie
dc.date.accessioned2022-05-11T14:28:42Z
dc.date.available2022-05-11T14:28:42Z
dc.date.issued2020
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Biyoloji Bölümü
dc.description.abstractWe conducted orthonairovirus RNA screening of 7043 tick specimens-representing 16 species-collected from various regions of Anatolia. In 602 pools, Crimean-Congo hemorrhagic fever virus (CCHFV) Europe 1 and 2 lineages were detected in seven pools (1.1 %) comprising Hyalomma marginatum, Hyalomma scupense, Rhipicephalus bursa, Rhipicephalus sanguineus sensu lato and Rhipicephalus turanicus ticks. In pools of Hyalomma aegyptium, we detected Tamdy virus (TAMV) and an unclassified nairovirus sequence. Next-generation se-quencing revealed complete coding regions of three CCHFV Europe 2 (AP92-like) viruses, TAMV and the novel orthonairovirus, tentatively named herein as Meram virus. We further performed in silico functional analysis of all available CCHFV Europe 2, TAMV, Meram and related virus genomes. The CCHFV Europe 2 viruses possessed several conserved motifs, including those with OTU-like cysteine protease activity. Probable recombinations were identified in L genome segments of CCHFV and TAMV. Through phylogeny reconstruction using individual genome segments, Meram virus emerged as a distinct virus among species within the Orthonairovirus genus. It further exhibited conserved motifs associated with RNA binding, encapsidation, signal peptidase cleavage, post -translational modification, RNA-dependent RNA polymerase and OTU-like activities. Bole tick virus 3 was also detected in two pools with CCHFV reactivity. Hereby, we describe a novel tick-associated orthonairovirus, in a CCHFV-endemic region with confirmed TAMV activity. Human and animal health impact of these viruses need to be addressed.
dc.description.sponsorshipArmed Forces Health Surveillance Board, Global Emerging Infections Surveillance and Response System (AFHSB-GEIS), United States of America (FY18 award US Army) [P0034_18_WR, W911QY-16-C-0160]; Food and Agriculture Organization of the United Nations (FAO) [GCP/TUR/055/GFF]
dc.description.sponsorshipThe study was funded in part by the Armed Forces Health Surveillance Board, Global Emerging Infections Surveillance and Response System (AFHSB-GEIS), United States of America (FY18 award P0034_18_WR (PI: Yvonne-Marie Linton) under US Army subcontract W911QY-16-C-0160). Some of the field collections were performed within the project The inventory and management plan of biological diversity in Konya and Karaman provinces, conducted by Nature Conservation Center Foundation one of the project partners supported by the Food and Agriculture Organization of the United Nations (FAO) (GCP/TUR/055/GFF). Neither funder/supporter had any role in study design, data collection, analysis, decision to publish, or manuscript preparation. The presented material reflects the views of the authors and should not be construed to represent those of the U.S. Department of the Army or the U.S. Department of Defense.
dc.identifier.doi10.1016/j.ttbdis.2020.101448
dc.identifier.issn1877-959X
dc.identifier.issn1877-9603
dc.identifier.issue5en_US
dc.identifier.pmid32723637
dc.identifier.scopus2-s2.0-85085931177
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.ttbdis.2020.101448
dc.identifier.urihttps://hdl.handle.net/20.500.11776/6913
dc.identifier.volume11
dc.identifier.wosWOS:000557360900006
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKar, Sırrı
dc.language.isoen
dc.publisherElsevier Gmbh
dc.relation.ispartofTicks and Tick-Borne Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCrimean-Congo hemorrhagic fever virus
dc.subjectNairovirus
dc.subjectBunyavirus
dc.subjectTamdy virus
dc.subjectBole tick virus
dc.subjectTicks
dc.subjectNairovirus
dc.subjectDiversity
dc.subjectStrain
dc.subjectEpidemiology
dc.subjectAlignment
dc.titleMultiple orthonairoviruses including Crimean-Congo hemorrhagic fever virus, Tamdy virus and the novel Meram virus in Anatolia
dc.typeArticle

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